Thyroid Complex by Rise-N-Shine — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
57% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size

30 Servings

Botanical with Nutrients Product Type

57% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin B12

50 mcg (2083% DV)

📊 20.8× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.05mg

Iodine

75 mcg (50% DV)

✅ Within RDA (0.5× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.075mg UL 1.1mg

Magnesium

100 mg (24% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 100mg

Zinc

4 mg (36.5% DV)

✅ Within RDA (0.4× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 4mg UL 40mg

Selenium

100 mcg (182% DV)

✅ 1.8× RDA — within safe limits 📚 172 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.1mg UL 0.4mg

Copper

100 mcg (11% DV)

✅ Within RDA (0.1× RDA of 0.9 mg) 📚 36 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 0.1mg UL 10mg

Manganese

1 mg (43.5% DV)

✅ Within RDA (0.4× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 1mg UL 11mg

Molybdenum

25 mcg (55.5% DV)

✅ Within RDA (0.6× RDA of 0.045 mg) 📚 2 studies — no high-quality reviews

RDA 0.045mg This product: 0.025mg UL 2mg

L-Tyrosine

150 mg

📊 Market median: 500.0mg (223 products) 📚 22 studies (Tier A: 0, B: 1)

This product: 150mg

Schisandra powder

120 mg

📊 Market median: 650.0mg (87 products) 📚 1 studies — no high-quality reviews

This product: 120mg

Ashwagandha root powder

100 mg

📊 Market median: 450.0mg (502 products) 📚 28 studies (Tier A: 0, B: 8)

This product: 100mg

Bladderwrack powder

25 mg

Cayenne Pepper powder

15 mg

Kelp

19 mg

Other Ingredients

Rice Flour Gelatin Magnesium Stearate Silicon Dioxide

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (89% of products) Nutrient (56% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Use: 1 capsule daily preferably with a meal or as directed by a healthcare.

⚠️ Warnings & Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Allergen warning: Contains soy and shellfish (kelp).

🧪 Formulation Notes

Contains natural and synthetic/artificial ingredients.

Advanced Premium Formula

Additional Information

Store in a cool, dry place.

Formulated In The USA GMP Quality Good manufacturing Practice Certification

Product Details

UPC / SKU 8 99130 01190 7

DSLD Entry Date 2024-07-25

Product Type Botanical with Nutrients

Form Capsule

Brand Rise-N-Shine

DSLD ID 313446

Data Updated 2026-04-11

Research Evidence

237 Research Sources

53 Avg Quality Score

83 Meta Analysis

74 Systematic Review

45 Rct

29 Clinical Trial

2 Guideline

2 Regulatory Source

1 Openfda Safety

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency

Systematic Review The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression

Meta Analysis Nutrients 2021

PubMed DOI

A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis

Systematic Review Irish journal of medical science 2024

PubMed DOI

B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis

Meta Analysis BMJ open gastroenterology 2020

PubMed DOI

B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes

Systematic Review The Cochrane database of systematic reviews 2024

PubMed DOI Cochrane

B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels

Meta Analysis Nutrition reviews 2024

PubMed DOI

B Relationship between vitamin B12 levels and motor development: A systematic review

Systematic Review Clinical nutrition ESPEN 2024

PubMed DOI

B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis

Meta Analysis Frontiers in endocrinology 2023

PubMed DOI

View all evidence for Vitamin B12 →