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P.R.F.

product on market Capsule Priority One Nutritional Supplements Safety: 98/100
98/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • 44% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins and calcium, which are supported by strong evidence for energy metabolism and bone health. Research indicates these nutrients are essential for cellular function and structural support. The profile maintains a high safety score, suggesting a low risk of adverse effects.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for P.R.F.
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
90
Servings
Botanical with Nutrients
Product Type
44%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (821% DV)
8.3× RDA — above typical dose 76 studies (A:0, B:33)
1 mg (77% DV)
Within RDA (0.8× RDA) 13 studies (A:0, B:1)
50 mg NE (313% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
10 mg (576% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Calcium
5 mg (1% DV)
1 mg (5% DV)
Within RDA (0.1× RDA) 263 studies (A:6, B:134)
Potassium
2 mg (1% DV)
Market median: 2000.0mg (63 products)
Market median: 300.0mg (214 products) 25 studies (A:0, B:6)
Market median: 250.0mg (60 products) 7 studies (A:0, B:1)
Hops Strobile Extract
13 mg
Chinese Skullcap root extract
25 mg
White Willow Bark Extract
50 mg
Market median: 60.0mg (107 products) 1 studies — no high-quality reviews
DL-Phenylalanine
150 mg
L-Glutamic Acid
25 mg

Other Ingredients

Silicon Dioxide Hypromellose Water, Purified
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendations: Take one (1) capsule as needed or as directed by your physician.

Warnings & Precautions

Warning: May interact with other medications, consult your physician before use.

Children with fevers and patients with ulcers or gastritis should not take white willow bark.

If you are pregnant or breast feeding, consult your physician before using this product.

Do not exceed six (6) capsules in a 24 hour period.

Keep out of reach of children.

For professional use only.

Formulation Notes

Contains no preservatives. Bisphenol-A (BPA) & Phthalate Free

Vegetarian formulation

Non-GMO

Additional Information

Keep container tightly closed, store in a cool, dry place.

GMP Certified

Metadata

Product Details

UPC / SKU8 15354 02111 9
DSLD Entry Date2024-10-24
Product TypeBotanical with Nutrients
FormCapsule
BrandPriority One Nutritional Supplements
DSLD ID310770
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.