🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 53% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Caplet(s) Serving Size
40 Servings
Other Combinations Product Type
53% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 {Calories}
Total Carbohydrates
2 Gram(s) (1% DV)
Vitamin C
60 mg (100% DV)
200 IU (50% DV)
✅ Within RDA (0.3× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.005mg UL 0.1mg
1 mg (67% DV)
✅ Within RDA (0.8× RDA of 1.2 mg) 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 1mg
1 mg (59% DV)
✅ Within RDA (0.8× RDA of 1.3 mg) 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 1mg
2 mg (100% DV)
✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 2mg UL 100mg
25 mcg (417% DV)
📊 10.4× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.025mg
2 mg (100% DV)
✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 2mg UL 11mg
Sodium
40 mg (2% DV)
1500 mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
Joint Shield(TM) Proprietary Blend
1104 mg
✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 50mg UL 3500mg
50 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 50mg
3 mg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 3mg UL 20mg

Other Ingredients

Cellulose Crospovidone Contains Less Than 2% of

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

DIRECTIONS FOR ADULT USE: TAKE TWO (2) CAPLETS PER DAY PREFERABLY WITH FOOD.

⚠️ Warnings & Precautions

CAUTION: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

Contains shellfish (shrimp, crab, lobster, crayfish) ingredients.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

🧪 Formulation Notes

Free of Gluten

Contains shellfish (shrimp, crab, lobster, crayfish) ingredients.

It contains 1,500 mg of Glucosamine, a key building block of cartilage.* With the addition of our Joint Shield(TM) Proprietary Blend, which contains Chondroitin, MSM and 5-LOXIN(R) Advanced, this revolutionary Energy Formula helps support energy metabolism and revitalize your joints to keep them jumpin’.*

GLUCOSAMINE CHONDROITIN PLUS JOINT SHIELD(TM)

With 5-LOXIN(R) ADVANCED

Additional Information

Proud sponsor of the ARTHRITIS FOUNDATION(R)

52399 00A B52399 MAB

#Based on two human studies with 5-LOXIN(R) Advanced where subjects rated their joint health over time, subjects’ joint health improved within 7 days, and continued to improve throughout the duration of the studies.

**52 week Nielsen ScanTrack data ending 8/25/12.

Part No. 22-52399

HELPS REVITALIZE YOUR JOINTS* KEY BUILDING BLOCK OF CARTILAGE*

2 PER DAY

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

SUPPORT ENERGY METABOLISM

#1 DOCTOR & PHARMACIST RECOMMENDED BRAND^

As a reminder, discuss the supplements and medications you take with your health care providers.

PROUD SPONSOR of the ARTHRITIS FOUNDATION(R) Rexall Sundown, Inc., the maker of Osteo Bi-Flex(R), is proud to support the Arthritis Foundation's efforts to help people take control of arthritis. For information about arthritis, contact the Foundation at 1-800-568-4045 or www.arthritis.org

NEW! SMOOTH WHITE COATING SAME FORMULA

The natural aging process can add excessive stress on your joints. Annoying flare-ups can strike at any time. Add Osteo Bi-Flex(R) Joint & Energy to your joint care regimen.

Starts working to improve joint comfort within 7 days.*#

Osteo Bi-Flex(R) is manufactured under the highest standards for product quality, purity and potency.

^Based on the results of a GfK Healthcare 2011 survey among physicians who recommend a brand of Glucosamine and Chondroitin or Glucosamine supplements; and the result of a Pharmacy Times Survey among pharmacists who recommend a “bone/joint strengthener” dietary supplement, 2006-2012.

Product Details

UPC / SKU 0 30768 18870 2
DSLD Entry Date 2014-02-26
Product Type Other Combinations
Form Other (e.g. tea bag)
DSLD ID 30801
Data Updated 2026-04-11

Research Evidence

371 Research Sources
54 Avg Quality Score
148 Meta Analysis
82 Systematic Review
71 Rct
62 Clinical Trial
2 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Other
1 Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021
View all evidence for Vitamin C →

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