Healthy Eyes Extra by 21st Century — Ingredients, Evidence & Safety

🟢 97/100

This product looks safe

Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
58% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)

Label Data

1 Tablet(s) Serving Size

36 Servings

Other Combinations Product Type

58% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A

300 mcg (33% DV)

Vitamin C

300 mg (333% DV)

Vitamin E

45 mg (300% DV)

✅ 3.0× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 45mg UL 1000mg

Riboflavin

3 mg (231% DV)

✅ 2.3× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 3mg

Niacin

40 mg (250% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 40mg UL 35mg

Calcium

107 mg (8% DV)

Zinc

40 mg (364% DV)

📊 3.6× RDA — above typical dose (UL: 40 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 40mg UL 40mg

Selenium

55 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.055mg UL 0.4mg

Copper

2 mg (222% DV)

✅ 2.2× RDA — within safe limits 📚 36 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 2mg UL 10mg

Manganese

5 mg (217% DV)

✅ 2.2× RDA — within safe limits 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 5mg UL 11mg

L-Glutathione

5 mg

Lutein

2 mg

📊 Market median: 10.0mg (105 products) 📚 1 studies (Tier A: 0, B: 1)

This product: 2mg

Other Ingredients

Cellulose Gelatin Stearic Acid Starch FD&C Yellow #6 Croscarmellose Sodium Dextrin Dextrose Gum Arabic Hydroxypropyl Methylcellulose Magnesium Stearate Maltodextrin Medium Chain Triglyceride PEG Polydextrose Silicon Dioxide Sodium Carboxymethylcellulose Sodium Citrate Titanium Dioxide Triacetin

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, adults take one (1) tablet daily with any meal or as directed by a healthcare provider. Do not exceed recommended dosage. Individual results may vary.

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

🧪 Formulation Notes

Gluten free

Healthy Eyes Extra with Lutein, Zinc & Vitamin B 21st Century Healthy Eyes Extra with antioxidants, Lutein, Zinc & B vitamins may help support eye health.

No added yeast.

Additional Information

Compare vs. Ocuvite Extra This product is not manufactured or distributed by Bausch & Lomb Pharmaceutical, Inc., owner of the registered trademark Ocuvite.

Store at room temperature.

Guaranteed Quality Laboratory Tested

Product Details

UPC / SKU 7 40985 27418 7

DSLD Entry Date 2023-12-14

Product Type Other Combinations

Form Tablet or Pill

Brand 21st Century

DSLD ID 304101

Data Updated 2026-04-11

Research Evidence

337 Research Sources

54 Avg Quality Score

161 Meta Analysis

68 Systematic Review

51 Rct

48 Clinical Trial

2 Other

2 Regulatory Source

1 Narrative Review

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis

Meta Analysis BMJ (Clinical research ed.) 2011

PubMed DOI

A Fortification of staple foods with vitamin A for vitamin A deficiency

Systematic Review The Cochrane database of systematic reviews 2019

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Narrative Review The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Journal of sport and health science 2023

PubMed DOI

A Food fortification with multiple micronutrients: impact on health outcomes in general population

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI

View all evidence for Vitamin A →