🟢 95/100

This product looks safe

  • Vitamin D: 0.125mg is 1.2× the Tolerable Upper Intake Level (0.1mg)
  • Niacin: 70mg is 2.0× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Vitamin D: 0.125mg is 1.2× the Tolerable Upper Intake Level (0.1mg)
⚠️ Niacin: 70mg is 2.0× the Tolerable Upper Intake Level (35mg)

Label Data

1 Packet(s) Serving Size
30 Servings
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C
1200 mg (1333% DV)
125 mcg (625% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.2× (UL: 0.1 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.125mg UL 0.1mg
70 mg (438% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.0× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 70mg UL 35mg
Calcium
40 mg (3% DV)
30 mg (273% DV)
✅ 2.7× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 30mg UL 40mg
Sodium
10 mg (1% DV)
750 mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 750mg
📊 Market median: 600.0mg (7 products) 📚 39 studies (Tier A: 2, B: 13)
This product: 600mg
📊 Market median: 260.0mg (249 products) 📚 156 studies (Tier A: 4, B: 61)
This product: 375mg
33 mg
📊 Market median: 500.0mg (159 products)
Median 500.0mg This product: 33mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 32mg
📊 Market median: 99.0mg (503 products) 📚 12 studies (Tier A: 0, B: 3)
RDA 700mg This product: 14mg UL 4000mg
Alpha D-Ribofuranose
13 mg
Xylitol
9 mg
L-Cysteine
8 mg
L-Glutathione
5 mg

Other Ingredients

Safflower Oil Gelatin Glycerin Water Hydroxypropyl Methylcellulose Microcrystalline Cellulose Magnesium Stearate Silica Microcrystalline Cellulose Croscarmellose Sodium Silica Magnesium Stearate Stearic Acid Hypromellose Medium Chain Triglyceride Hydroxypropyl Cellulose Hydroxypropyl Methylcellulose Magnesium Stearate Silica

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take one packet daily with food or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: If pregnant, nursing, or taking medications, consult your healthcare practitioner before use.

Keep out of the reach of children.

Notice: This product contains vitamin D at a level that exceeds the adult tolerable upper intake level. It is highly recommended that serum 25(OH)- and 1,25(OH)2-vitamin D be monitored every 60-90 days while consuming this product to ensure that levels remain in acceptable range.

Practitioner Exclusive

This product is produced in a facility that produces products containing soy, fish, and crustacean shellfish.

🧪 Formulation Notes

Immune Defense Pack Gear up with Immune Defense Pack. With ingredients like antioxidants, polyphenols, and high-potency vitamins C, D, and zinc, this arsenal of products is primed to support a healthy immune response as well as cardiovascular function.

What's in the pack? Quercetin: Quercetin promotes a healthy immune response and provides excellent support for antioxidant processes, helping protect cells from harmful free radicals. Quercetin also supports cardiovascular health, helps maintain healthy blood pressure levels already in the normal range, and promotes healthy HDL function. Vitamin C: Vitamin C supports healthy immune function by helping promote natural killer cell and white blood cell activities. EGCG: This ingredient from decaffeinated green tea leaf extract is categorized as a flavonoid polyphenol, which can help promote antioxidant processes in the body. N-acetylcysteine (NAC): A metabolite of the sulphur - containing amino acid cysteine that stimulates the biosynthesis of glutathione, a key antioxidant produced in the body. Glutathione plays an important role in protecting the body against oxidative stress. Vitamin D3: This is the most bioavailable form of supplement vitamin D. Vitamin D provides unique support for long-term immune health and well-being. Some research suggests that vitamin D sufficiency may contribute to healthy cardiovascular function. Zinc: A mineral that plays an essential role in maintaining healthy immune system function. In addition, zinc is a component of numerous enzymes in the body related to energy metabolism, bone mineralization, and protein synthesis.

The Metagenics Difference Metagenics is a professional nutraceutical company that formulates, manufactures, and continually evaluates nutritional products in clinical practice. Each formula represents years of collective - research to deliver optimized foundation nutrition and targeted health support.

Each packet contains: 1 D3 5000 softgel (golden yellow), 1 Quercetin 500 capsule (yellow), 1 Ultra Potent C 1000mg tablet (off-white with speckles), 2 Immune Active capsules (yellow orange).

Products included are non-GMO and gluten-free.

Targeted nutrients to support a healthy immune response and cardiovascular function

Contains no more than 4% caffeine.

Additional Information

Storage: Store in a cool, dry place.

Product Details

UPC / SKU 7 55571 94714 7
DSLD Entry Date 2023-09-25
Product Type Other Combinations
Form Other (e.g. tea bag)
Brand Metagenics
DSLD ID 295900
Data Updated 2026-04-11

Research Evidence

371 Research Sources
54 Avg Quality Score
148 Meta Analysis
82 Systematic Review
71 Rct
62 Clinical Trial
2 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Other
1 Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021
View all evidence for Vitamin C →

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