Fermented Coenzyme B Complex by New Chapter — Ingredients, Evidence & Safety

🟢 94/100

This product looks safe

Niacin: 45mg is 1.3× the Tolerable Upper Intake Level (35mg)
Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)
69% of ingredients have research evidence

D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 45mg is 1.3× the Tolerable Upper Intake Level (35mg)

⚠️ Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size

90 Servings

Botanical with Nutrients Product Type

69% Evidence Coverage

Supplement Facts — Evidence Check

Thiamine

5 mg (417% DV)

📊 4.2× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 5mg

Riboflavin

3.9 mg (300% DV)

✅ 3.0× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 3.9mg

Niacin

45 mg (281% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 45mg UL 35mg

Vitamin B6

9 mg (529% DV)

📊 6.9× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 9mg UL 100mg

Folate

666 mcg DFE (167% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 666.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 666mg UL 1.0mg

Vitamin B12

120 mcg (5000% DV)

📊 50.0× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.12mg

Biotin

300 mcg (1000% DV)

📊 10.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.3mg

Pantothenic Acid

45 mg (900% DV)

📊 9.0× RDA — above typical dose 📚 1 studies — no high-quality reviews

RDA 5mg This product: 45mg

Stress and Energy Support Blend

150 mg

Cardio Support Blend

60 mg

Immune Support Blend

56.2 mg

Turmeric

7 mg

📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)

This product: 7mg

Ginger Rhizome Extract

4 mg

📊 Market median: 250.0mg (337 products) 📚 125 studies (Tier A: 1, B: 41)

This product: 4mg

Other Ingredients

Soy Flour Saccharomyces cerevisiae Orange, Powder Alfalfa, Powder Lactobacillus acidophilus Bifidobacterium bifidum Lactobacillus rhamnosus Papain Bromelain Gum Acacia Silica Lac Resin Carnauba Wax

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Kosher Gluten Free

Product Information

📋 Directions for Use

Suggested Use: One tablet daily. Can be taken anytime, even on an empty stomach.

⚠️ Warnings & Precautions

Caution: As with any dietary supplement, you should advise your healthcare professional of the use of this product if you have a medical condition or take medication. If you are nursing, pregnant, or considering pregnancy, consult your healthcare professional prior to using this product.

Keep out of reach of children.

Contains: Fermented soy.

🧪 Formulation Notes

Certified gluten-free by NSF; 100% vegetarian; No artificial flavors or colors.

Formulated for absorption Energy & nervous system support

Made with organic vegetables & herbs

Non GMO Project Verified nongmoproject.org NSF Certified Gluten-free

OU (Kosher)

Certified Organic by International Certification Services, Inc., Meidna, ND, USA

Additional Information

The New Chapter Money-Back Guarantee We proudly stand behind every product we make. However, if you are not satisfied, please visit www.newchapter.com/guarantee for refund details. Please recycle this bottle after use.

ICS (International Certification Services) Non GMO Project Verified nongmoproject.org NSF Certified Gluten-free OU (Kosher)

Product Details

DSLD Entry Date 2023-04-21

Product Type Botanical with Nutrients

Form Tablet or Pill

Brand New Chapter

DSLD ID 288193

Data Updated 2026-04-11

Research Evidence

100 Research Sources

56 Avg Quality Score

48 Systematic Review

30 Meta Analysis

13 Rct

6 Clinical Trial

1 Cochrane Review

1 Regulatory Source

B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Systematic Review The Cochrane database of systematic reviews 2013

PubMed DOI Cochrane

B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

Systematic Review Nutritional neuroscience 2023

PubMed DOI

B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis

Meta Analysis BMJ open 2022

PubMed DOI

B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis

Systematic Review Intensive care medicine 2022

PubMed DOI

B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis

Meta Analysis Pain medicine (Malden, Mass.) 2020

PubMed DOI

B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Meta Analysis Critical care medicine 2021

PubMed DOI

B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2022

PubMed DOI

B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023

PubMed DOI

B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

Systematic Review The Cochrane database of systematic reviews 2004

PubMed Cochrane

View all evidence for Thiamine →