UNIQUE B+
93/100
This product looks safe
- Niacin: 200mg is 5.7× the Tolerable Upper Intake Level (35mg)
- Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
- 82% of ingredients have research evidence
D
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ Niacin: 200mg is 5.7× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
1 Capsule(s)
Serving Size
100
Servings
Other Combinations
Product Type
82%
Evidence Coverage
Supplement Facts — Evidence Check
15 mg
(1250% DV)
📊 12.5× RDA — above typical dose
📚 76 studies (Tier A: 0, B: 33)
17 mg
(1308% DV)
📊 13.1× RDA — above typical dose
📚 12 studies (Tier A: 0, B: 1)
200 mg
(1250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 5.7× (UL: 35 mg)
📚 193 studies (Tier A: 5, B: 63)
20 mg
(1176% DV)
📊 15.4× RDA — above typical dose (UL: 100 mg)
📚 113 studies (Tier A: 3, B: 35)
680 mcg DFE
(170% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 680.0× (UL: 1.0 mg)
📚 225 studies (Tier A: 10, B: 105)
6 mcg
(250% DV)
✅ 2.5× RDA — within safe limits
📚 138 studies (Tier A: 1, B: 44)
300 mcg
(1000% DV)
📊 10.0× RDA — above typical dose
📚 26 studies (Tier A: 0, B: 11)
100 mg
(2000% DV)
📊 20.0× RDA — above typical dose
📚 1 studies — no high-quality reviews
25 mg
(5% DV)
📊 Market median: 125.0mg (294 products)
📚 36 studies (Tier A: 1, B: 7)
40 mg
📊 Market median: 550.0mg (217 products)
📚 29 studies (Tier A: 0, B: 5)
25 mg
📊 Market median: 500.0mg (9 products)
Other Ingredients
Hydroxypropyl Methylcellulose
Water
Microcrystalline Cellulose
Ascorbyl Palmitate
Label Claims — Verification
❓
Nutrient
❓
All Other
All Other (99% of products)
Structure/Function (83% of products)
Nutrient (47% of products)
Target Groups
Adult (18 - 50 Years)
Gluten Free
Dairy Free
Product Information
📋 Directions for Use
Suggested use: 1 capsule daily with food or as directed by a healthcare professional.
⚠️ Warnings & Precautions
Do not use if shrinkwrap is broken or missing.
Keep out of reach of children.
🧪 Formulation Notes
Vitamin B
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and corn. Contains no artificial colors, flavors or preservatives.
Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.
Additional Information
Store in a cool, dry place (59 degrees F-85 degrees F) away from direct light.
Doctor tested: Application-based science 50+ years of excellence!
Product Details
UPC / SKU
8 28054 77728 6
DSLD Entry Date
2023-05-24
Product Type
Other Combinations
Form
Capsule
Brand
A.C. Grace Company
DSLD ID
285412
Data Updated
2026-04-11
Research Evidence
100
Research Sources
56
Avg Quality Score
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B
Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
B
Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
B
Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
B
Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
B
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
B
Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
B
Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
B
The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
B
Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
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