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B-Supreme

product on market Capsule Designs for Health Safety: 92/100
92/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • NatureFolate Blend: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)
  • 80% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The B-vitamin complex, including thiamine, riboflavin, and niacin, is supported by strong evidence for its role in energy metabolism and neurological function. The NatureFolate blend provides folate in a bioactive form to support cellular health. Clinical research indicates these nutrients are generally safe and effective for maintaining metabolic homeostasis.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

NatureFolate Blend: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B-Supreme
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg (8333% DV)
83.3× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (3846% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
50 mg NE (313% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
50 mg (2941% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
340 mcg DFE (85% DV)
Exceeds UL by 340.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
250 mcg (10417% DV)
104.2× RDA — above typical dose 139 studies (A:1, B:44)
2000 mcg (6667% DV)
66.7× RDA — above typical dose 27 studies (A:0, B:11)
100 mg (2000% DV)
20.0× RDA — above typical dose 2 studies — no high-quality reviews
30 mg (5% DV)
Within RDA (0.1× RDA) 38 studies (A:1, B:7)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Cellulose Silicon Dioxide Vegetable Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Recommended Use: As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.

Warnings & Precautions

For Professional Use Only

Formulation Notes

Coenzymated B-Vitamin complex

Gluten free formula Dairy free formula Soy free formula Non GMO ingredients

Vegetarian formula

Metadata

Product Details

DSLD Entry Date2022-08-23
Product TypeOther Combinations
FormCapsule
BrandDesigns for Health
DSLD ID276111
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.