B-CALMplex

product on market Capsule Natural Rhythm 🟢 Safety: 97/100
Brand: Natural Rhythm
🟢 97/100

This product looks safe

  • Vitamin B3: 55mg is 1.6× the Tolerable Upper Intake Level (35mg)
  • 82% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Vitamin B3: 55mg is 1.6× the Tolerable Upper Intake Level (35mg)

Label Data

1 Vegetable Capsule(s) Serving Size
90 Servings
Other Combinations Product Type
82% Evidence Coverage

Supplement Facts — Evidence Check

55 mg (3667% DV)
📊 45.8× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 55mg
55 mg (3235% DV)
📊 42.3× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 55mg
55 mg (275% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.6× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 55mg UL 35mg
55 mg (2750% DV)
📊 42.3× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 55mg UL 100mg
200 mcg (50% DV)
✅ Within RDA (0.5× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.2mg UL 1.0mg
12 mcg (200% DV)
📊 5.0× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.012mg
100 mcg (33% DV)
📊 3.3× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.1mg
55 mg (550% DV)
📊 11.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 55mg
55 mg
📊 Market median: 500.0mg (9 products)
This product: 55mg
55 mg
✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 55mg UL 3500mg
55 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 55mg

Other Ingredients

Microcrystalline Cellulose Vegetable Cellulose vegetarian Leucine

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested use: As a dietary supplement, take 1 capsule daily with a meal, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.

Keep out of reach of children.

🧪 Formulation Notes

Restore your rhythm Support your immune system

Fight Stress & Anxiety B-CALMplex is a premium stress B complex formula that helps you manage stress, support your immune system function, and reduce irritability. Find Calm & Balance B-CALMplex contains an optimal balance of essential B vitamins, which help promote cardiovascular health and overall cellular renewal. B vitamins help decrease stress, anxiety, and fatigue while helping to boost your energy and mental focus.

Made in the USA

Pure. Max absorption. Easy on stomach.

A premium stress B complex formula

To support stress management, proper nerve function, and relaxation

Vegetarian

Gluten free

Non-GMO

Color of this product may vary due to color variations of the natural ingredients.

Additional Information

GMP Good Manufacturing Practice Quality Product

Store in a cool, dry place.

Product Details

UPC / SKU 7 64804 31744 2
DSLD Entry Date 2022-08-23
Product Type Other Combinations
Form Capsule
Brand Natural Rhythm
DSLD ID 271231
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
PubMed DOI Cochrane
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
PubMed Cochrane
View all evidence for Thiamine →

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