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B-Complex

product on market Capsule Patient One 1 MediNutritionals Safety: 93/100
93/100

This product looks safe

  • Niacin: 75mg is 2.1× the Tolerable Upper Intake Level (35mg)
  • Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)
  • 82% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The B-complex vitamins, including folate and pyridoxine, are supported by strong evidence for their roles in energy metabolism and neurological function. These nutrients act as essential cofactors for cellular processes throughout the body. The overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 75mg is 2.1× the Tolerable Upper Intake Level (35mg)

Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B-Complex
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
82%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

87.5 mg (7292% DV)
72.9× RDA — above typical dose 76 studies (A:0, B:33)
25 mg (1923% DV)
19.2× RDA — above typical dose 13 studies (A:0, B:1)
75 mg (469% DV)
Exceeds UL by 2.1× (UL: 35 mg) 196 studies (A:5, B:63)
25 mg (1471% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
666 mcg DFE (167% DV)
Exceeds UL by 666.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
400 mcg (16667% DV)
166.7× RDA — above typical dose 139 studies (A:1, B:44)
300 mcg (1000% DV)
10.0× RDA — above typical dose 27 studies (A:0, B:11)
100 mg (2000% DV)
20.0× RDA — above typical dose 2 studies — no high-quality reviews
20 mg (4% DV)
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
25 mg
Market median: 500.0mg (9 products) 7 studies — no high-quality reviews
18 mg
15.0× RDA — above typical dose 76 studies (A:0, B:33)

Other Ingredients

Vegetable Cellulose Rice Flour Leucine
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Take 1 capsule as a dietary supplement, preferably with a meal, or as directed by your health practitioner.

Warnings & Precautions

Caution: If you are pregnant, nursing, or taking any medications, consult your health practitioner before use.

Discontinue use and consult your health practitioner if any adverse reactions occur.

Keep out of reach of children.

Use only if safety seal is intact.

Formulation Notes

Vegetarian

Gluten free Non-GMO

Free Of: Milk, egg, fish, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast and gluten. Free of ingredients derived from GMOs.

Active Essentials with Quatrefolic

Additional Information

Store in a cool, dry place.

BPA free

Exclusive Professional Formulas

Metadata

Product Details

UPC / SKU8 53959 00445 8
DSLD Entry Date2021-05-22
Product TypeOther Combinations
FormCapsule
BrandPatient One 1 MediNutritionals
DSLD ID249165
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.