🟢 90/100

This product looks safe

  • Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
  • Vitamin B6: 150mg is 1.5× the Tolerable Upper Intake Level (100mg)
  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 82% of ingredients have research evidence
F Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
⚠️ Vitamin B6: 150mg is 1.5× the Tolerable Upper Intake Level (100mg)
⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Caplet(s) Serving Size
100 Servings
Other Combinations Product Type
82% Evidence Coverage

Supplement Facts — Evidence Check

150 mg (12500% DV)
📊 125.0× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 150mg
150 mg (11538% DV)
📊 115.4× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 150mg
150 mg (938% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 4.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 150mg UL 35mg
150 mg (8824% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.5× (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 150mg UL 100mg
667 mcg DFE (167% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 667mg UL 1.0mg
150 mcg (6250% DV)
📊 62.5× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.15mg
150 mcg (500% DV)
📊 5.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.15mg
150 mg (3000% DV)
📊 30.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 150mg
63 mg (11% DV)
✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 63mg UL 3500mg
📊 Market median: 500.0mg (9 products)
This product: 150mg
150 mcg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 0.15mg

Other Ingredients

Microcrystalline Cellulose Hydroxypropyl Methylcellulose Hydroxypropylcellulose Dicalcium Phosphate Calcium Silicate Stearic Acid Silicon Dioxide Magnesium Stearate caranauba wax Rice Bran Powder Ethylcellulose Triacetin Diacetylated Monoglycerides Oleic Acid Polyethylene Glycol

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Kosher Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take one caplet daily.

⚠️ Warnings & Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use to weeks prior to surgery. Niacin may cause a temporary flushing reaction. Inform your physician of this product's biotin content before any lab test.

🧪 Formulation Notes

Metabolism & energy production Immune & nervous system functions Healthy brain, skin, hair and nails

Potency verified by GNC procedure #5103. Conforms to USP <2091> for weight.

No sugar, no artificial colors, no artificial flavors, sodium free, no wheat, gluten free, no corn, no soy, no dairy.

Ko Kosher Service

Additional Information

Store in a cool, dry place.

100-day supply

Ko Kosher Service

Product Details

UPC / SKU 0 48107 17753 9
DSLD Entry Date 2021-01-22
Product Type Other Combinations
Form Other (e.g. tea bag)
Brand GNC
DSLD ID 242998
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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