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EC Matrixx

product on market Tablet or Pill Metagenics Safety: 96/100
96/100

This product looks safe

  • Folate: 130mg is 130.0× the Tolerable Upper Intake Level (1.0mg)
  • 90% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains a complex of B vitamins, including folate, B12, and biotin, which are essential for energy metabolism and neurological function. Strong clinical evidence supports the role of these nutrients in maintaining cellular health and supporting homocysteine levels. The profile is associated with a high safety score of 96/100.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 130mg is 130.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for EC Matrixx
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
90
Servings
Other Combinations
Product Type
90%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

20 mg (125% DV)
1.4× RDA — within safe limits 196 studies (A:5, B:63)
2 mg (118% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
130 mcg DFE (33% DV)
Exceeds UL by 130.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
83 mcg (3458% DV)
34.6× RDA — above typical dose 139 studies (A:1, B:44)
200 mcg (667% DV)
6.7× RDA — above typical dose 27 studies (A:0, B:11)
10 mg (2% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
2 mg (18% DV)
Within RDA (0.2× RDA) 263 studies (A:6, B:134)
40 mcg (73% DV)
Within RDA (0.7× RDA) 173 studies (A:0, B:67)
Tetrahydro-Iso-Alpha Acids Complex
100 mg
100 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)

Other Ingredients

Microcrystalline Cellulose Maltodextrin Cellulose Stearic Acid Silica Calcium Silicate Croscarmellose Sodium Coating
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take two tablets initially, followed by one tablet three times daily with food, or as recommended by your healthcare practitioner.

Warnings & Precautions

Caution: Do not use if pregnant or nursing. Consult your healthcare practitioner if taking other nutritional supplements or medications.

Keep out of the reach of children.

Formulation Notes

EC Matrixx is designed to support the health of connective tissue by positively influencing the extracellular matrix, a key component of tendons, ligaments, and cartilage. This advanced, mechanism-specific formula features berberine and THIAA, which have been shown in laboratory research to influence MMP-13 an enzyme associated with the health of connective tissues.

This product is non-GMO, gluten-free and vegetarian.

This product is non-GMO, gluten-free and vegetarian.

Support for healthy connective tissue

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GF Certified Gluten-free

Practitioner exclusive

Metadata

Product Details

UPC / SKU7 55571 91783 6
DSLD Entry Date2020-03-24
Product TypeOther Combinations
FormTablet or Pill
BrandMetagenics
DSLD ID216329
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.