EC Matrixx

product on market Tablet or Pill Metagenics 🟢 Safety: 96/100
Brand: Metagenics
🟢 96/100

This product looks safe

  • Folate: 130mg is 130.0× the Tolerable Upper Intake Level (1.0mg)
  • 90% of ingredients have research evidence
C Label Compliance Grade

Product Label

📄 Open Full PDF View on NIH DSLD →
📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Safety Alerts

⚠️ Folate: 130mg is 130.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size
90 Servings
Other Combinations Product Type
90% Evidence Coverage

Supplement Facts — Evidence Check

20 mg (125% DV)
✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 20mg UL 35mg
2 mg (118% DV)
✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 2mg UL 100mg
130 mcg DFE (33% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 130.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 130mg UL 1.0mg
83 mcg (3458% DV)
📊 34.6× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.083mg
200 mcg (667% DV)
📊 6.7× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.2mg
10 mg (2% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 10mg
2 mg (18% DV)
✅ Within RDA (0.2× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 2mg UL 40mg
40 mcg (73% DV)
✅ Within RDA (0.7× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.04mg UL 0.4mg
Tetrahydro-Iso-Alpha Acids Complex
100 mg
100 mg
📊 Market median: 500.0mg (234 products) 📚 95 studies (Tier A: 0, B: 35)
This product: 100mg

Other Ingredients

Microcrystalline Cellulose Maltodextrin Cellulose Stearic Acid Silica Calcium Silicate Croscarmellose Sodium Coating

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Directions: Take two tablets initially, followed by one tablet three times daily with food, or as recommended by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Do not use if pregnant or nursing. Consult your healthcare practitioner if taking other nutritional supplements or medications.

Keep out of the reach of children.

🧪 Formulation Notes

EC Matrixx is designed to support the health of connective tissue by positively influencing the extracellular matrix, a key component of tendons, ligaments, and cartilage. This advanced, mechanism-specific formula features berberine and THIAA, which have been shown in laboratory research to influence MMP-13 an enzyme associated with the health of connective tissues.

This product is non-GMO, gluten-free and vegetarian.

This product is non-GMO, gluten-free and vegetarian.

Support for healthy connective tissue

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GF Certified Gluten-free

Practitioner exclusive

Product Details

UPC / SKU 7 55571 91783 6
DSLD Entry Date 2020-03-24
Product Type Other Combinations
Form Tablet or Pill
Brand Metagenics
DSLD ID 216329
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI Cochrane
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
PubMed DOI
View all evidence for Niacin →

Compare Similar Products

Rezistaf LifeLink 100
Coenzymated B-3 25 mg Source Naturals 100
Vitamin B Complex Simply Supplements 100
Test X180 Boost Force Factor 100
8-Hour Alert
8-Hour Alert MHP Maximum Human Performance 100
View all Niacin products →
Niacin research & evidence Best Niacin rankings All Niacin products More from Metagenics View on NIH DSLD →