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Nootropic Stimulant

product on market Tablet or Pill Addrena Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 47% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines B vitamins for energy metabolism with stimulants like guarana and bitter orange to increase alertness. Yohimbe bark extract is included for its potential metabolic effects, though evidence for these ingredients varies from moderate to limited. The profile is generally considered safe based on the provided safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Nootropic Stimulant
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Other Combinations
Product Type
47%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1.5 mg (7.5% DV)
Within RDA (0.1× RDA) 196 studies (A:5, B:63)
500 mcg (8333.5% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
600 mg
Market median: 495.0mg (70 products)
250 mg
Market median: 983.0mg (16 products) 7 studies (A:0, B:1)
Yohimbe bark extract
100 mg
Within RDA (0.1× RDA) 38 studies (A:1, B:7)
Market median: 500.0mg (861 products) 61 studies (A:4, B:13)
Bacopa extract
45 mg
40 mg
Market median: 180.0mg (239 products) 49 studies (A:1, B:19)
DMAE
37.5 mg
White Willow bark extract
30 mg
Market median: 500.0mg (223 products) 24 studies (A:0, B:1)
Piperine
3 mg
Vinpocetine
2.5 mg
50 mcg
Market median: 0.15mg (41 products)

Other Ingredients

Stearic Acid Dicalcium Phosphate Microcrystalline Cellulose Croscarmellose Sodium Magnesium Stearate Silicon Dioxide Pharmaceutical Glaze
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one tablet daily. Pills can be split in half at first to judge it's strength, which we recommend. Not recommended to take more than two pills in one day. Slowly build up the dose if you take more than one.

Warnings & Precautions

Warning: Not intended for persons under the age of 18.

Do not use if pregnant or nursing. Consult a health care professional prior to consumption if you have any pre-existing medical conditions or any prescription medication.

Do not consume with any caffeine or stimulants. Improper use of this product will not improve results and is potentially hazardous to a person's health. Use only as directed.

Keep out of reach of children.

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU7 48252 28689 5
DSLD Entry Date2019-10-23
Product TypeOther Combinations
FormTablet or Pill
BrandAddrena
DSLD ID206821
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.