🟢 84/100

This product is generally safe

  • Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
  • Vitamin B6: 150mg is 1.5× the Tolerable Upper Intake Level (100mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 69% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
⚠️ Vitamin B6: 150mg is 1.5× the Tolerable Upper Intake Level (100mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Tablet(s) Serving Size
210 Servings
Other Combinations Product Type
69% Evidence Coverage

Supplement Facts — Evidence Check

150 mg (10000% DV)
📊 125.0× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 150mg
150 mg (8823% DV)
📊 115.4× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 150mg
150 mg (750% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 4.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 150mg UL 35mg
150 mg (7500% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.5× (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 150mg UL 100mg
800 mcg (200% DV)
✅ 2.0× RDA — within safe limits 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.8mg UL 1.0mg
160 mcg (2667% DV)
📊 66.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.16mg
160 mcg (53% DV)
📊 5.3× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.16mg
150 mg (1500% DV)
📊 30.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 150mg
✅ Within RDA (0.3× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 150mg UL 3500mg
100 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 100mg
25 mg
📊 Market median: 500.0mg (9 products)
This product: 25mg
GABA
200 mg
Proprietary Serenity Complex
220 mg

Other Ingredients

Dicalcium Phosphate Xanthan Gum Stearic Acid Magnesium Stearate Povidone Cellulose

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take 1 tablet daily.

⚠️ Warnings & Precautions

KEEP OUT OF THE REACH OF CHILDREN.

DO NOT USE IF SAFETY SEAL UNDER CAP IS BROKEN OR MISSING.

🧪 Formulation Notes

No sugar, salt, starch, yeast, corn, wheat, lactose, gluten, milk, egg, fish products, artificial coloring, flavoring, or preservatives added.

Additional Information

Store in a cool dry place. Do not refrigerate. Please recycle.

MADE IN THE USA

SPECIALTY FORMULAS

Time Released High potency B vitamins with GABA & Herbs†

Product Details

UPC / SKU 8 12720 01601 4
DSLD Entry Date 2011-11-25
Product Type Other Combinations
Form Tablet or Pill
DSLD ID 1780
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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