Coenzyme Q10 is a fat-soluble molecule that functions as an essential mitochondrial electron carrier and antioxidant. Research indicates it may play a role in managing cardiovascular health, migraine prophylaxis, and mitigating side effects from statin use.

Evidence by Condition

Heart Failure Moderate

CoQ10 is studied for its potential role in managing heart failure (PMID: 35608922).

Migraine Moderate

Supplementation may reduce the frequency and severity of migraine attacks (PMID: 33402403).

Statin-induced Myopathy Moderate

CoQ10 may help alleviate muscle-related adverse events caused by statin use (PMID: 33999383).

Hypertension Weak

Some evidence suggests potential for blood pressure lowering in primary hypertension (PMID: 26935713).

Polycystic Ovary Syndrome (PCOS) Moderate

CoQ10 supplementation may improve clinical outcomes in patients with PCOS (PMID: 35941510).

Cancer (Anthracycline-induced cardiotoxicity) Moderate

CoQ10 may provide cardioprotective benefits for patients receiving anthracyclines (PMID: 21678342).

Metabolic Syndrome Moderate

Supplementation may improve adipokine levels and reduce inflammation (PMID: 32375340).

Effective Doses

Dose ranges were not specified in the provided research summaries.

Key Findings

CoQ10 supplementation may reduce the frequency and severity of migraine attacks (PMID: 33402403).
CoQ10 may mitigate statin-associated muscle symptoms (PMID: 33999383).
CoQ10 may improve adipokine levels and alleviate inflammation in metabolic syndrome (PMID: 32375340).

Limitations

The strength of evidence varies significantly across conditions, with some meta-analyses relying on very small sample sizes (e.g., N=30 for hypertension).

Safety & Interactions

No specific drug interactions or contraindications were identified in the provided research summaries.

AI-generated summary from 201 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.

Dietary Reference Intakes

Source: IOM/NAM Dietary Reference Intakes · Dietary Reference Intakes: Coenzyme Q10

Drug-Supplement Interactions

Anticonvulsants 🔴 Critical

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of carbamazepine (anticonvulsants), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of carbamazepine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

GI Prokinetics 🔴 Critical

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of cisapride (gi-prokinetics), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of cisapride. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Immunosuppressants 🔴 Critical

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of cyclosporine (immunosuppressants), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of cyclosporine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Theophylline 🔴 Critical

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of theophylline (theophylline), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of theophylline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

ADHD Medications 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of atomoxetine (adhd-medications), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of atomoxetine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antibiotics 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of clarithromycin (antibiotics), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of clarithromycin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antidiabetic Drugs 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of repaglinide (antidiabetic-drugs), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of repaglinide. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antiemetics 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of ondansetron (antiemetics), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of ondansetron. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antifungals 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of fluconazole (antifungals), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of fluconazole. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antipsychotics 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of haloperidol (antipsychotics), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of haloperidol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Antitussives 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of dextromethorphan (antitussives), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of dextromethorphan. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Benzodiazepines 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of midazolam (benzodiazepines), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of midazolam. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Beta Blockers 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP2D6, which decreases metabolism of CYP2D6 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of metoprolol (beta-blockers), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of metoprolol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Beta-2 Agonists 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of salmeterol (beta2-agonists), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of salmeterol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

CFTR Modulators 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of ivacaftor (cftr-modulators), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of ivacaftor. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Calcium Channel Blockers 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of nifedipine (calcium-channel-blockers), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of nifedipine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Chemotherapy 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of doxorubicin (chemotherapy), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of doxorubicin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Corticosteroids 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of prednisone (corticosteroids), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of prednisone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Leukotriene Antagonists 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of montelukast (leukotriene-antagonists), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of montelukast. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Opioids 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of methadone (opioids), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of methadone. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Oral Contraceptives 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of ethinylestradiol (oral-contraceptives), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of ethinylestradiol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

PDE5 Inhibitors 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of sildenafil (pde5-inhibitors), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of sildenafil. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

PPIS 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of omeprazole (ppis), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of omeprazole. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

SNRI 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of venlafaxine (snri), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of venlafaxine. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

SSRI 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of sertraline (ssri), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of sertraline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Tricyclic Antidepressants 🟡 Moderate

Mechanism: Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect: Increased plasma levels of amitriptyline (tricyclic-antidepressants), potentially leading to toxicity or enhanced adverse effects.

Management: Monitor for increased adverse effects of amitriptyline. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Evidence: cyp-inferred

Warfarin 🟡 Moderate

Mechanism: CoQ10 is structurally similar to vitamin K and may reduce warfarin effectiveness.

Effect: Reduced anticoagulant effect; decreased INR

Management: Monitor INR if starting/stopping CoQ10. May need warfarin dose adjustment.

Evidence: possible

Antihypertensives 🟢 Minor

Mechanism: CoQ10 may have mild blood pressure-lowering effects, potentially additive with antihypertensives.

Effect: Possible additive blood pressure reduction

Management: Monitor blood pressure. Generally a beneficial interaction.

Evidence: possible

Statins 🟢 Minor

Mechanism: Statins inhibit HMG-CoA reductase, which also produces CoQ10. Supplemental CoQ10 may offset statin-induced CoQ10 depletion.

Effect: CoQ10 may reduce statin-associated muscle symptoms (evidence mixed)

Management: CoQ10 supplementation is generally safe with statins. May help muscle symptoms.

Evidence: inconclusive

⚠️ This information is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before combining supplements with medications.

Claims vs. Evidence

100% Evidence-Backed

0% Unsupported

87% Structure/Function

Claim Type	% of Products	Evidence Required	Status
All Other	99%	Tier D (Unclassified)	✅ Supported
Structure/Function	87%	Tier C (DSHEA Structure/Function (no pre-approval))	✅ Supported
Nutrient	13%	Tier D (Unknown)	✅ Supported
Qualified Health	1%	Tier B (FDA Qualified Health Claim)	✅ Supported
No Claim	0%	Tier D (No claim on label)	✅ Supported

Research by Topic

Coq10 143 studies

MET Cardioprotective interventions for cancer patients receiving...

MET Efficacy and Safety of Coenzyme Q10 Supplementation in the T...

+140 more

Coq10 Heart 14 studies

MET Coenzyme Q10 for heart failure

MET Effects of coenzyme Q10 supplementation on statin-induced my...

MET Effects of coenzyme Q10 supplementation on myopathy in stati...

+11 more

Selenium Cardiovascular 10 studies

RCT Dietary Supplementation with Selenium and Coenzyme Q10 Preve...

RCT Selenium and coenzyme Q10 improve the systemic redox status ...

RCT Selenium and Coenzyme Q10 Supplementation Improves Renal Fun...

+7 more

Coq10 Migraine 8 studies

MET Coenzyme Q10 supplementation for prophylaxis in adult patien...

MET Effect of coenzyme Q10 supplementation on clinical features ...

RCT The synergistic effects of nano-curcumin and coenzyme Q10 su...

+5 more

Coq10 Blood Pressure 7 studies

MET Blood pressure lowering efficacy of coenzyme Q10 for primary...

MET Dose-Response Effect of Coenzyme Q10 Supplementation on Bloo...

+4 more

Dietary Supplement General 7 studies

CLI Study With Two Coenzyme Q10 Products

CLI Comparative Single-dose Bioavailability Clinical Study of Di...

CLI Creatine and Ubiquinol for Sperm Quality

+4 more

Coq10 Fertility 2 studies

SYS Effects of Carnitine and Coenzyme Q10 on Sperm Quality and P...

RCT Coenzyme Q10 Impact on Ovarian Reserve Measures and the Intr...

Coq10 Statin 2 studies

MET Effects of coenzyme Q10 on statin-induced myopathy: a meta-a...

RCT The effect of 8 weeks of physical training on muscle perform...

Calcium 1 studies

MET Coenzyme Q10 for heart failure

Selenium 1 studies

MET Systematic Review and Meta-analysis on Effect of Carnitine, ...

Red Yeast Rice 1 studies

RCT Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed,...

Curcumin Metabolic 1 studies

RCT Effects of curcumin and/or coenzyme Q10 supplementation on m...

Royal Jelly 1 studies

RCT Royal jelly plus coenzyme Q10 supplementation improves high-...

Vitamin A 1 studies

CLI Efficacy and Safety of Coenzyme Q10 in Pediatric Hemodialysi...

Tryptophan Sleep 1 studies

RCT Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplemen...

Vitamin C 1 studies

CLI Effect of CoQ10 Plus Selenium Supplementation on Clinical Ou...

Vitamin D 1 studies

CLI Coenzyme Q10 in Relation to the Antioxidative Vitamins, Oxid...

⚠️ FDA Safety Data

Safety Profile - coenzyme Q10

Adverse Event Profile: Coq10

Research Evidence (202)

Meta Analysis: 86 Systematic Review: 62 Rct: 28 Clinical Trial: 17 Regulatory Source: 4 Other: 2 Narrative Review: 1 Openfda Safety: 1

A Coenzyme Q10 for heart failure

Meta Analysis The Cochrane database of systematic reviews 2021 n=1573

BACKGROUND: Coenzyme Q10, or ubiquinone, is a non-prescription nutritional supplement. It is a fat-soluble molecule that acts as an electron carrier in mitochondria, and as a coenzyme for mitochondrial enzymes. Coenzyme Q10 deficiency may be associat...

PubMed DOI Cochrane

A Cardioprotective interventions for cancer patients receiving anthracyclines

Meta Analysis The Cochrane database of systematic reviews 2011 n=1619

**van et al., 2011** | Cochrane Database Syst Rev | Meta Analysis van Dalen Elvira C, Caron Huib N, ... Kremer Leontien Cm. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst Rev. 2011-Jun-15;2011(6):C...

PubMed DOI

A Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis

Meta Analysis BMJ open 2021 n=371

OBJECTIVE: To determine the effects of coenzyme Q10 (CoQ10) for reduction in the severity, frequency of migraine attacks and duration of headache in adult patients with migraine. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Cochrane Cen...

PubMed DOI

A Effects of coenzyme Q10 supplementation on statin-induced myopathy: a meta-analysis of randomized controlled trials

Meta Analysis Irish journal of medical science 2022 n=472

BACKGROUND: Statins can trigger a series of muscle-related adverse events, commonly referred to collectively as statin-induced myopathy. Although coenzyme Q10 (CoQ10) is widely used as a supplement in statin therapy, there is little clinical evidence...

PubMed DOI

B Cardioprotective interventions for cancer patients receiving anthracyclines

Meta Analysis The Cochrane database of systematic reviews 2008 n=1403

**van et al., 2008** | Cochrane Database Syst Rev | Meta Analysis van Dalen E C, Caron H N, ... Kremer L C M. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst Rev. 2008-Apr-16(2):CD003917. doi:10.100...

PubMed DOI

B Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension

Meta Analysis The Cochrane database of systematic reviews 2016 n=30

BACKGROUND: Blood pressure is a commonly measured risk factor for non-fatal and fatal cardiovascular adverse events such as heart attacks and strokes. Clinical trials have suggested that coenzyme Q10, a non-prescription nutritional supplement, can ef...

PubMed DOI Cochrane

B Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis

Meta Analysis Reproductive sciences (Thousand Oaks, Calif.) 2023 n=1021

**Zhang et al., 2023** | Reprod Sci | Meta Analysis Zhang Tianqing, He Qi, ... Hu Hengjing. Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis. Reprod Sci. 2023-Apr...

PubMed DOI

B Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials

Meta Analysis International journal of molecular sciences 2020 n=318

**Dludla et al., 2020** | Int J Mol Sci | Meta Analysis Dludla Phiwayinkosi V, Orlando Patrick, ... Tiano Luca. Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndr...

PubMed DOI

B Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis

Meta Analysis Journal of nutritional science 2025 n=389

Statins are effective drugs for lowering hypercholesterolemia and preventing cardiovascular diseases. They can cause various side effects, in particular statin-associated muscle symptoms (SAMS) associated with mitochondrial dysfunction and micronutri...

PubMed DOI

B Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension

Meta Analysis The Cochrane database of systematic reviews 2009 n=96

BACKGROUND: Studies have shown that coenzyme Q10 deficiency is associated with cardiovascular disease. Hypertension is a commonly measured surrogate marker for non-fatal and fatal cardiovascular endpoints such as heart attacks and strokes. Clinical t...

PubMed DOI Cochrane

B Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose-response meta-analysis of randomized controlled trials

Meta Analysis Nutritional neuroscience 2020 n=221

Objective: Coenzyme Q10 is an antioxidant and an essential mitochondrial cofactor which has been suggested to improve the clinical features of migraine. Several randomized clinical trials have examined the effects of Coenzyme Q10 on migraine with inc...

PubMed DOI

B Nutrition and bipolar disorder: a systematic review

Systematic Review Nutritional neuroscience 2023 n=986

**Gabriel et al., 2023** | Nutr Neurosci | Systematic Review Gabriel Fernanda C, Oliveira Manoela, ... Lafer Beny. Nutrition and bipolar disorder: a systematic review. Nutr Neurosci. 2023-Jul;26(7):637-651. doi:10.1080/1028415X.2022.2077031 INTRODUCT...

PubMed DOI

B Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials

Meta Analysis The Journal of clinical endocrinology and metabolism 2022 n=2794

**Liu et al., 2022** | J Clin Endocrinol Metab | Meta Analysis Liu Zhihao, Tian Zezhong, ... Yang Yan. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials. J Clin Endocrinol Metab. 2022...

PubMed DOI

B Interventions for the management of long covid (post-covid condition): living systematic review

Systematic Review BMJ (Clinical research ed.) 2024 n=708

**Zeraatkar et al., 2024** | BMJ | Systematic Review Zeraatkar Dena, Ling Michael, ... Busse Jason W. Interventions for the management of long covid (post-covid condition): living systematic review. BMJ. 2024-Nov-27;387:e081318. doi:10.1136/bmj-2024-...

PubMed DOI

B The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials

Meta Analysis Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2017 n=899

**Zhu et al., 2017** | Neurol Sci | Meta Analysis Zhu Zhen-Guo, Sun Miao-Xuan, ... Xie Cheng-Long. The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials. Neurol Sci. 2017-Feb;38(2):215-224. do...

PubMed DOI

B Coenzyme Q10 for Parkinson's disease

Meta Analysis The Cochrane database of systematic reviews 2011 n=452

**Liu et al., 2011** | Cochrane Database Syst Rev | Meta Analysis Liu Jia, Wang Luning, ... Xia Yinyin. Coenzyme Q10 for Parkinson's disease. Cochrane Database Syst Rev. 2011-Dec-07(12):CD008150. doi:10.1002/14651858.CD008150.pub2 BACKGROUND: A numbe...

PubMed DOI

B The effects of coenzyme Q10 supplementation on biomarkers of exercise-induced muscle damage, physical performance, and oxidative stress: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition ESPEN 2024 n=830

**Talebi et al., 2024** | Clin Nutr ESPEN | Meta Analysis Talebi Sepide, Pourgharib Shahi Mohammad Hossein, ... Mohammadi Hamed. The effects of coenzyme Q10 supplementation on biomarkers of exercise-induced muscle damage, physical performance, and ox...

PubMed DOI

B The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial

Rct Nutritional neuroscience 2021 n=100

Introduction: Migraine is a disabling neurovascular disorder characterized by increasing levels of pro-inflammatory cytokines and oxidative stress biomarkers. Curcumin and coenzyme Q10 (CoQ10) can exert neuroprotective effects through modulation of i...

PubMed DOI

B Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis

Meta Analysis Annals of medicine 2024 n=1529

**Lin et al., 2024** | Ann Med | Meta Analysis Lin Guangyao, Li Xuanling, ... Xu Lianwei. Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis. Ann Med. 20...

PubMed DOI

B The auxiliary effect of oral nutritional supplements on fertility in women with diminished ovarian reserve: a systematic review and meta-analysis

Meta Analysis Annals of medicine 2025 n=2773

**Li et al., 2025** | Ann Med | Meta Analysis Li Xuanling, Zhao Qian, ... Xu Lianwei. The auxiliary effect of oral nutritional supplements on fertility in women with diminished ovarian reserve: a systematic review and meta-analysis. Ann Med. 2025-Dec...

PubMed DOI

B Effect of micronutrients on fertility and aneuploidy rates in human conceptions: a systematic review and meta-analysis

Meta Analysis Reproductive biomedicine online 2026 n=1810

**Schütz et al., 2026** | Reprod Biomed Online | Meta Analysis Schütz David, Lettorp Kirstine Huong, ... Hoffmann Eva R. Effect of micronutrients on fertility and aneuploidy rates in human conceptions: a systematic review and meta-analysis. Reprod Bi...

PubMed DOI

B Treatment for mitochondrial disorders

Meta Analysis The Cochrane database of systematic reviews 2012 n=30

**Pfeffer et al., 2012** | Cochrane Database Syst Rev | Meta Analysis Pfeffer Gerald, Majamaa Kari, ... Chinnery Patrick F. Treatment for mitochondrial disorders. Cochrane Database Syst Rev. 2012-Apr-18;2012(4):CD004426. doi:10.1002/14651858.CD004426...

PubMed DOI

B Coenzyme Q10 for heart failure

Meta Analysis The Cochrane database of systematic reviews 2014 n=60

**Madmani et al., 2014** | Cochrane Database Syst Rev | Meta Analysis Madmani Mohammed E, Yusuf Solaiman Ahmad, ... Kadro Waleed. Coenzyme Q10 for heart failure. Cochrane Database Syst Rev. 2014-Jun-02(6):CD008684. doi:10.1002/14651858.CD008684.pub2 ...

PubMed DOI

B Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Advances in nutrition (Bethesda, Md.) 2022 n=1831

Previous studies have shown beneficial effects of coenzyme Q10 (CoQ10) supplementation on blood pressure (BP). However, the optimal intake of CoQ10 for BP regulation in patients with cardiometabolic disorders is unknown, and its effect on circulating...

PubMed DOI

B WITHDRAWN: Coenzyme Q10 for Parkinson's disease

Systematic Review The Cochrane database of systematic reviews 2012 n=452

**Liu et al., 2012** | Cochrane Database Syst Rev | Systematic Review Liu Jia, Wang Lu-Ning, ... Xia Yinyin. WITHDRAWN: Coenzyme Q10 for Parkinson's disease. Cochrane Database Syst Rev. 2012-May-16;2012(5):CD008150. doi:10.1002/14651858.CD008150.pub3...

PubMed DOI

B Dietary Supplementation with Selenium and Coenzyme Q10 Prevents Increase in Plasma D-Dimer While Lowering Cardiovascular Mortality in an Elderly Swedish Population

Rct Nutrients 2021 n=106

A low intake of selenium is associated with increased cardiovascular mortality. This could be reduced by supplementation with selenium and coenzyme Q10. D-dimer, a fragment of fibrin mirroring fibrinolysis, is a biomarker of thromboembolism, increase...

PubMed DOI

B Coenzyme Q10 supplementation in rheumatic diseases: A systematic review

Systematic Review Clinical nutrition ESPEN 2024 n=483

**Freire et al., 2024** | Clin Nutr ESPEN | Systematic Review Freire de Carvalho Jozélio, Skare Thelma. Coenzyme Q10 supplementation in rheumatic diseases: A systematic review. Clin Nutr ESPEN. 2024-Feb;59:63-69. doi:10.1016/j.clnesp.2023.11.016 Coen...

PubMed DOI

B Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis

Meta Analysis Advances in nutrition (Bethesda, Md.) 2024 n=2617

**Shang et al., 2024** | Adv Nutr | Meta Analysis Shang Yujie, Song Nannan, ... Wu Minghua. Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis. Adv Nutr. 2024-Aug;15(8):100273. doi:10.1016/j.advnut.2024.1002...

PubMed DOI

B Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Review

Systematic Review Nutrients 2025 n=809

**Dorczok et al., 2025** | Nutrients | Systematic Review Dorczok Marie Celine, Mittmann Gloria, ... Steiner-Hofbauer Verena. Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic Revi...

PubMed DOI

B Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials

Meta Analysis BMC cardiovascular disorders 2017 n=2149

**Lei et al., 2017** | BMC Cardiovasc Disord | Meta Analysis Lei Li, Liu Yan. Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials. BMC Cardiovasc Disord. 2017-Jul-24;17(1):196. doi:10.1186/s12872-017-0628-9 B...

PubMed DOI

B Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis

Meta Analysis Journal of infection in developing countries 2024 n=1364

**Zeng et al., 2024** | J Infect Dev Ctries | Meta Analysis Zeng Min, Chen Zhi, ... Pang Yusheng. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. ...

PubMed DOI

B Association of the COQ2 V393A variant with risk of multiple system atrophy in East Asians: a case-control study and meta-analysis of the literature

Meta Analysis Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2016

**Zhao et al., 2016** | Neurol Sci | Meta Analysis Zhao QuanZhen, Yang Xinglong, ... Xu Yanming. Association of the COQ2 V393A variant with risk of multiple system atrophy in East Asians: a case-control study and meta-analysis of the literature. Neur...

PubMed DOI

B The effects of a nutraceutical combination on plasma lipids and glucose: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Pharmacological research 2016 n=1670

**Pirro et al., 2016** | Pharmacol Res | Meta Analysis Pirro Matteo, Mannarino Massimo Raffaele, ... Sahebkar Amirhossein. The effects of a nutraceutical combination on plasma lipids and glucose: A systematic review and meta-analysis of randomized co...

PubMed DOI

B Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

Systematic Review Journal of translational medicine 2020 n=6316

**Kim et al., 2020** | J Transl Med | Systematic Review Kim Do-Young, Lee Jin-Seok, ... Son Chang-Gue. Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med. 2020-Jan-06;18(1):...

PubMed DOI

B Effect of Coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis

Meta Analysis Atherosclerosis 2020 n=321

BACKGROUND AND AIMS: Statin associated muscle symptoms are common and affect adherence to statin treatment. The objective of this study was to assess whether patients with statin-associated myalgia can be successfully treated with Coenzyme Q10 (CoQ10...

PubMed DOI

B Diabetes, Age, and Duration of Supplementation Subgroup Analysis for the Effect of Coenzyme Q10 on Oxidative Stress: A Systematic Review and Meta-Analysis

Meta Analysis Complementary medicine research 2021 n=972

**Hajiluian et al., 2021** | Complement Med Res | Meta Analysis Hajiluian Ghazaleh, Heshmati Javad, ... Shidfar Farzad. Diabetes, Age, and Duration of Supplementation Subgroup Analysis for the Effect of Coenzyme Q10 on Oxidative Stress: A Systematic ...

PubMed DOI

B Systematic Review and Meta-analysis on Effect of Carnitine, Coenzyme Q10 and Selenium on Pregnancy and Semen Parameters in Couples With Idiopathic Male Infertility

Meta Analysis Urology 2022 n=3304

**Sharma et al., 2022** | Urology | Meta Analysis Sharma Aditya P, Sharma Gopal, Kumar Rajeev. Systematic Review and Meta-analysis on Effect of Carnitine, Coenzyme Q10 and Selenium on Pregnancy and Semen Parameters in Couples With Idiopathic Male Inf...

PubMed DOI

B Effects of Mitoquinone (MitoQ) Supplementation on Aerobic Exercise Performance and Oxidative Damage: A Systematic Review and Meta-analysis

Systematic Review Sports medicine - open 2024 n=188

**Gonzalo-Skok et al., 2024** | Sports Med Open | Systematic Review Gonzalo-Skok Oliver, Casuso Rafael A. Effects of Mitoquinone (MitoQ) Supplementation on Aerobic Exercise Performance and Oxidative Damage: A Systematic Review and Meta-analysis. Spor...

PubMed DOI

B Effects of Carnitine and Coenzyme Q10 on Sperm Quality and Pregnancy Rates in Men with Unexplained Infertility: A Systematic Review and Network Meta-Analysis

Systematic Review Reproductive sciences (Thousand Oaks, Calif.) 2025

AIMS: To study and explore the effects of oral Carnitine and Coenzyme Q10 on the quality of sperm and the rate of pregnancy in males with unexplained infertility. BACKGROUND: Preventing and reducing oxidative stress is essential for male infertility ...

PubMed DOI

B Available and future treatments for atypical parkinsonism. A systematic review

Systematic Review CNS neuroscience & therapeutics 2019

**Moretti et al., 2019** | CNS Neurosci Ther | Systematic Review Moretti Davide Vito. Available and future treatments for atypical parkinsonism. A systematic review. CNS Neurosci Ther. 2019-Feb;25(2):159-174. doi:10.1111/cns.13068 AIMS: Success in tr...

PubMed DOI

B Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials

Meta Analysis Journal of the American Heart Association 2018 n=575

Background Previous studies have demonstrated a possible association between the induction of coenzyme Q10 (CoQ10) after statin treatment and statin-induced myopathy. However, whether CoQ10 supplementation ameliorates statin-induced myopathy remains ...

PubMed DOI

B The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials

Meta Analysis European journal of medical research 2018 n=1776

**Qu et al., 2018** | Eur J Med Res | Meta Analysis Qu Hua, Meng Yan-Yan, ... Shi Da-Zhuo. The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials. Eur J Med Res. 2018-Nov-10...

PubMed DOI

B Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials

Meta Analysis Molecular nutrition & food research 2023 n=1517

**Hou et al., 2023** | Mol Nutr Food Res | Meta Analysis Hou Shanshan, Tian Zezhong, ... Yang Yan. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analy...

PubMed DOI

B Selenium and coenzyme Q10 improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals

Rct Free radical biology & medicine 2023 n=434

BACKGROUND: Serum sulfhydryl groups (R-SH, free thiols) reflect the systemic redox status in health and disease, and may be amenable to therapeutic modulation. Since R-SH are readily oxidized by reactive species, oxidative stress is characterized by ...

PubMed DOI

B Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial

Rct Nutrients 2023 n=105

**Angelopoulos et al., 2023** | Nutrients | Rct Angelopoulos Nicholas, Paparodis Rodis D, ... Livadas Sarantis. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipid...

PubMed DOI

B Scientific Opinion on CoQ10 and cardiovascular health

Regulatory Source EFSA Journal 2010

**Authority**: European Food Safety Authority (EFSA) **Claim Type**: art13.1 **Substance**: coq10 **DOI**: 10.2903/j.efsa.2010.1849 **URL**: https://doi.org/10.2903/j.efsa.2010.1849

DOI

B Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

Systematic Review Nutrients 2018

**Cicero et al., 2018** | Nutrients | Systematic Review Cicero Arrigo F G, Colletti Alessandro, Bellentani Stefano. Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence. Nutrients. 2018-Aug-23;10(9). do...

PubMed DOI

B The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials

Meta Analysis Lipids in health and disease 2018 n=267

**Jorat et al., 2018** | Lipids Health Dis | Meta Analysis Jorat Mohammad Vahid, Tabrizi Reza, ... Asemi Zatollah. The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta...

PubMed DOI

B Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis

Systematic Review Human reproduction update 2020 n=1124

**Zhang et al., 2020** | Hum Reprod Update | Systematic Review Zhang Yu, Zhang Chao, ... Huang Hefeng. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod ...

PubMed DOI

B Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation

Meta Analysis Health technology assessment (Winchester, England) 2022 n=2250

**Claxton et al., 2022** | Health Technol Assess | Meta Analysis Claxton Lindsay, Simmonds Mark, ... Stewart Lesley A. Coenzyme Q10 to manage chronic heart failure with a reduced ejection fraction: a systematic review and economic evaluation. Health ...

PubMed DOI

Showing top 50 of 202 sources, sorted by quality score.

Details

Coenzyme Q10

Overview

Coenzyme Q10 is a bioactive compound tracked in the biomedical knowledge base.

Also known as: coq10, ubiquinol, ubiquinone, coenzyme q

Role in Health

Detailed overview pending — this entity has sources compiled across multiple verticals.

Related Verticals

See sources-index for all verified sources referencing Coenzyme Q10.

Safety Considerations

Safety data extraction pending.

Sources

See linked source pages for full provenance.

Related Supplements

Selenium 12 shared sources Carnitine 6 shared sources Curcumin 3 shared sources Creatine 3 shared sources Vitamin D 2 shared sources Probiotics 2 shared sources Dhea 2 shared sources Vitamin E 1 shared sources

Frequently Asked Questions

What is Coenzyme Q10 and what does it do?

Coenzyme Q10 is a fat-soluble molecule that acts as an antioxidant and an essential part of your cells' energy production. It is primarily studied for its potential benefits in supporting cardiovascular health and managing certain inflammatory conditions.

Can CoQ10 help with migraines?

There is moderate evidence suggesting that CoQ10 supplementation may reduce both the frequency and the severity of migraine attacks. It is often researched as a way to prevent migraines from occurring.

Does CoQ10 help with muscle pain from statins?

Yes, there is moderate evidence that CoQ10 may help alleviate muscle-related side effects, known as myopathy, caused by statin use. This is because statins can lower the body's natural levels of CoQ10.

Is CoQ10 good for heart health?

There is moderate evidence that CoQ10 may play a role in managing heart failure. Additionally, it may provide cardioprotective benefits for patients receiving certain types of cancer treatments, such as anthracyclines.

What is the recommended dose of CoQ10?

There is no official Dietary Reference Intake (DRI) for CoQ10, but a typical supplemental dose is between 50 and 200 mg per day. You should consult a healthcare professional to determine the appropriate dose for your specific needs.

Are there any dangerous interactions with CoQ10?

There is a moderate interaction risk with the blood thinner Warfarin, as CoQ10 may reduce the medication's effectiveness. There is also a minor interaction with statins, though supplementation may actually help mitigate some of the drug's muscle-related side effects.

Can CoQ10 help with PCOS or high blood pressure?

There is moderate evidence that CoQ10 may improve clinical outcomes for individuals with Polycystic Ovary Syndrome (PCOS). However, the evidence regarding its ability to lower blood pressure in patients with hypertension is currently weak.

Answers generated from research evidence. Not medical advice.