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Coq10 × Antipsychotics

MODERATE Cyp-Inferred Evidence

Mechanism

Coq10 is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

Effect

Increased plasma levels of haloperidol (antipsychotics), potentially leading to toxicity or enhanced adverse effects.

Management

Monitor for increased adverse effects of haloperidol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination carries a moderate risk because CoQ10 can slow down how your body breaks down certain antipsychotic medications. This may cause the medication to build up in your bloodstream, which could increase the risk of side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Research

Supporting Research

Cardioprotective interventions for cancer patients receiving anthracyclines
PMID:21678342 DOI 2011
Cardioprotective interventions for cancer patients receiving anthracyclines
PMID:18425895 DOI 2008
Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis
PMID:35941510 DOI 2023
Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials
PMID:32375340 DOI 2020
Nutrition and bipolar disorder: a systematic review
PMID:35608150 DOI 2023
Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials
PMID:36337001 DOI 2022
Interventions for the management of long covid (post-covid condition): living systematic review
PMID:39603702 DOI 2024
The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials
PMID:27830343 DOI 2017
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.