Home/ Supplements/ Betaine/ Homocystrol + TMG

Homocystrol + TMG

product on market Capsule Douglas Laboratories Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 80% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines B-vitamins and trimethylglycine to support homocysteine metabolism. Strong evidence indicates that B-6, B-12, and folic acid are effective in lowering homocysteine levels. Choline and TMG provide additional methyl groups to facilitate this biochemical process.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Homocystrol + TMG
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
90
Servings
Other Combinations
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

15 mg (500% DV)
11.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
400 mcg (100% DV)
Within RDA (1.0× RDA) 226 studies (A:10, B:105)
300 mcg (5000% DV)
125.0× RDA — above typical dose 139 studies (A:1, B:44)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
23.5 mg
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)

Other Ingredients

Cellulose Vegetable Stearate Vegetable Stearate Vegetable Stearate Silica
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Suggested Usage: As a dietary supplement, adults take 1 capsule daily or as directed by your healthcare professional.

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

Tamper resistant package, do not use if outer seal is missing.

Formulation Notes

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

Additional Information

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)

Formula #79803

Metadata

Product Details

UPC / SKU3 10539 00663 4
DSLD Entry Date2012-02-23
Product TypeOther Combinations
FormCapsule
BrandDouglas Laboratories
DSLD ID6232
Data Updated2026-04-11
Research

Research Evidence

23
Research Sources
47
Avg Quality
18
Rct
3
Systematic Review
1
Meta Analysis
1
Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016 PubMed DOI
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009 PubMed DOI
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017 PubMed DOI
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015 PubMed DOI
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023 PubMed DOI
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019 PubMed DOI
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition PubMed DOI
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN PubMed DOI
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition PubMed DOI
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009 PubMed DOI
View all evidence for Betaine →
Compare

Similar Products

TMG (Trimethylglycine) With Folic Acid & B-12
Kirkman · Capsule
100
Candida Cleanse
Balance One · Capsule
100
HCl with Pepsin
Solaray · Capsule
100
Betaine HCL 250 mg
Solaray · Capsule
100
GI-One
Patient One MediNutritionals · Capsule
100
View all Betaine products →
Betaine research Best Betaine All Betaine products More from Douglas Laboratories View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.