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HCl with Pepsin

product on market Capsule Solaray Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 25% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Betaine HCl and pepsin are used to increase gastric acidity and support protein digestion, with moderate evidence supporting their use for hypochlorhydria. Papaya and glutamic acid provide additional enzymatic and metabolic support for nutrient breakdown. Overall, clinical evidence for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for HCl with Pepsin
Open Full PDF View on NIH DSLD →
Details

Label Data

1 VegCap(s)
Serving Size
180
Servings
Other Combinations
Product Type
25%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

250 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Pepsin
150 mg
Papaya
100 mg

Other Ingredients

Maltodextrin Vegetable Cellulose Capsule Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Use only as directed. Take one VegCap with a meal.

Warnings & Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product. Do not take this product when your meal consists only of salad or fruit. If you have hyper (high) acid stomach or ulcers, consult a physician before using this product.

Do not use if you are pregnant.

Formulation Notes

Digestive health Lab vertified

Discussion: This formula is intended to provide digestive support by promoting the production of hydrochloric acid and assisting in the breakdown of protein. Ideal for use after meals high in protein.

HCL with Pepsin 230 mg

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 76280 04816 2
DSLD Entry Date2021-10-22
Product TypeOther Combinations
FormCapsule
BrandSolaray
DSLD ID254292
Data Updated2026-04-11
Research

Research Evidence

23
Research Sources
47
Avg Quality
18
Rct
3
Systematic Review
1
Meta Analysis
1
Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016 PubMed DOI
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009 PubMed DOI
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017 PubMed DOI
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015 PubMed DOI
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023 PubMed DOI
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019 PubMed DOI
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition PubMed DOI
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN PubMed DOI
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition PubMed DOI
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.