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TMG (Trimethylglycine) With Folic Acid & B-12

product on market Capsule Kirkman Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Trimethylglycine, folic acid, and vitamin B12 are involved in homocysteine metabolism and methylation processes. There is strong evidence supporting the role of B-vitamins in neurological function and cellular health. Research indicates these ingredients generally maintain a high safety profile when used as directed.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for TMG (Trimethylglycine) With Folic Acid & B-12
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
250
Servings
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

200 mcg (50% DV)
Within RDA (0.5× RDA) 226 studies (A:10, B:105)
6 mcg (100% DV)
2.5× RDA — within safe limits 139 studies (A:1, B:44)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Trimethylglycine Microcrystalline Cellulose Folic Acid Magnesium Stearate Silicon Dioxide Methylcobalamin Plant Cellulose Capsule
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

SUGGESTED USE: 1-4 capsules daily or as directed by a physician.

Warnings & Precautions

KEEP OUT OF THE REACH OF CHILDREN.

Formulation Notes

FREE OF: Sugar, starch, soy, wheat, casein, gluten, milk, corn, preservatives, yeast, gelatin, flavorings, colorings, peanuts, tree nuts or fish.

CASEIN & GLUTEN FREE

HYPOALLERGENIC

Additional Information

(503)694-1600

IMPORTANT: STORE IN A COOL DRY PLACE AND TIGHTLY CAPPED.

Best Used By: 2013

028/250

Metadata

Product Details

DSLD Entry Date2013-09-25
Product TypeOther Combinations
FormCapsule
BrandKirkman
DSLD ID25340
Data Updated2026-04-11
Research

Research Evidence

23
Research Sources
47
Avg Quality
18
Rct
3
Systematic Review
1
Meta Analysis
1
Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016 PubMed DOI
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009 PubMed DOI
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017 PubMed DOI
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015 PubMed DOI
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023 PubMed DOI
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019 PubMed DOI
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition PubMed DOI
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN PubMed DOI
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition PubMed DOI
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009 PubMed DOI
View all evidence for Betaine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.