GI-One

product on market Capsule Patient One MediNutritionals 🟢 Safety: 100/100
Brand: Patient One MediNutritionals
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 17% of ingredients have research evidence
B Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
Other Combinations Product Type
17% Evidence Coverage

Supplement Facts — Evidence Check

Amylase
35 mg
100 mg
📊 Market median: 200.0mg (136 products) 📚 3 studies — no high-quality reviews
This product: 100mg
50 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 50mg
Cellulase
40 mg
Lipase
5 mg
Lactase
10 mg
11.1 mg
📊 Market median: 80.0mg (20 products) 📚 334 studies (Tier A: 8, B: 183)
This product: 11.1mg
Papaya powder
100 mg
Papain
9 mg
Pancreatin 4X
200 mg
Protease
3.25 mg
37.5 mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 37.5mg

Other Ingredients

Vegetable Cellulose Rice Flour Leucine

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (100% of products) Structure/Function (82% of products) Nutrient (8% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Use: Take 1 capsule at the start of the afternoon and evening meals as a dietary supplement, or as directed by a health practitioner. May take an additional capsule with each meal as needed.

⚠️ Warnings & Precautions

Caution: If you are pregnant, nursing, or taking any medications, consult your health practitioner before use.

Discontinue use and consult your health practitioner if any adverse reactions occur.

Keep out of reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

Gluten free Non-GMO Free of: milk, egg, fish, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast and gluten. Free of ingredients derived from GMOs.

Color may vary due to natural ingredients.

Comprehensive digestive enzyme complex with lactospore 15 billion/g

Additional Information

BPA Free

Exclusive Professional Formulas

Product Details

UPC / SKU 8 53959 00498 4
DSLD Entry Date 2021-05-22
Product Type Other Combinations
Form Capsule
Brand Patient One MediNutritionals
DSLD ID 249295
Data Updated 2026-04-11

Research Evidence

23 Research Sources
47 Avg Quality Score
18 Rct
3 Systematic Review
1 Meta Analysis
1 Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016
PubMed DOI
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009
PubMed DOI
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017
PubMed DOI
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015
PubMed DOI
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023
PubMed DOI
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019
PubMed DOI
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition
PubMed DOI
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN
PubMed DOI
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition
PubMed DOI
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009
PubMed DOI
View all evidence for Betaine →

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