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Active Methylated B Complex

product on market Capsule Approved Science Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 70% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This complex contains B vitamins and Quatrefolic, which are supported by strong evidence for supporting cellular energy metabolism and cognitive function. These methylated forms are generally well-absorbed and utilized by the body. Research indicates these nutrients play critical roles in maintaining neurological health and metabolic processes.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Active Methylated B Complex
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
70%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

50 mg (4166% DV)
41.7× RDA — above typical dose 76 studies (A:0, B:33)
10 mg (769% DV)
7.7× RDA — above typical dose 13 studies (A:0, B:1)
25 mg NE (156% DV)
1.8× RDA — within safe limits 196 studies (A:5, B:63)
10 mg (588% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Quatrefolic
680 mg DFE (170% DV)
500 mcg (20833% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
500 mcg (1666% DV)
16.7× RDA — above typical dose 27 studies (A:0, B:11)
50 mg (1000% DV)
10.0× RDA — above typical dose 2 studies — no high-quality reviews
150 mg (27% DV)
Within RDA (0.3× RDA) 38 studies (A:1, B:7)
250 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Cellulose
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take two capsules daily, (one in the morning and one in the afternoon) with meals and an 8oz. glass of water.

Warnings & Precautions

Caution: Do not exceed recommended dose.

Pregnant women or nursing mothers, children under 18, individuals with a known medical condition, and those taking anticoagulant or antiplatelet medications, should consult with a physician before taking this or any other dietary supplement.

Pregnant women or nursing mothers, children under 18, individuals with a known medical condition, and those taking anticoagulant or antiplatelet medications, should consult with a physician before taking this or any other dietary supplement. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Formulation Notes

Manufactured in the USA with global ingredients according to current Good Manufacturing Practice (cGMP) and conforms to the tested ingredient grade, strength and purity of industry quality standards.

GMO Free Made with ingredients

Vegan friendly

Active Methylated B Complex with patented methylfolate with Quatrefolic high absorption folate

Premium grade High Potency Trusted Fast Natural Formula Optimal strength GMP Certified

100% vegan friendly

Additional Information

Store at room temperature.

Vegan friendly Made in USA No animal testing GMP Good manufacturing practice Quality products

Metadata

Product Details

UPC / SKUX004KWQSMJ
DSLD Entry Date2025-09-25
Product TypeOther Combinations
FormCapsule
BrandApproved Science
DSLD ID339385
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.