Active Methylated B Complex

product on market Capsule Approved Science 🟢 Safety: 100/100
Brand: Approved Science
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 70% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
70% Evidence Coverage

Supplement Facts — Evidence Check

50 mg (4166% DV)
📊 41.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 50mg
10 mg (769% DV)
📊 7.7× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 10mg
25 mg NE (156% DV)
✅ 1.8× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 25mg UL 35mg
10 mg (588% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
Quatrefolic
680 mg DFE (170% DV)
500 mcg (20833% DV)
📊 208.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.5mg
500 mcg (1666% DV)
📊 16.7× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.5mg
50 mg (1000% DV)
📊 10.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 50mg
150 mg (27% DV)
✅ Within RDA (0.3× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 150mg UL 3500mg
250 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 250mg

Other Ingredients

Cellulose

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Dairy Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take two capsules daily, (one in the morning and one in the afternoon) with meals and an 8oz. glass of water.

⚠️ Warnings & Precautions

Caution: Do not exceed recommended dose.

Pregnant women or nursing mothers, children under 18, individuals with a known medical condition, and those taking anticoagulant or antiplatelet medications, should consult with a physician before taking this or any other dietary supplement.

Pregnant women or nursing mothers, children under 18, individuals with a known medical condition, and those taking anticoagulant or antiplatelet medications, should consult with a physician before taking this or any other dietary supplement. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

🧪 Formulation Notes

Manufactured in the USA with global ingredients according to current Good Manufacturing Practice (cGMP) and conforms to the tested ingredient grade, strength and purity of industry quality standards.

GMO Free Made with ingredients

Vegan friendly

Active Methylated B Complex with patented methylfolate with Quatrefolic high absorption folate

Premium grade High Potency Trusted Fast Natural Formula Optimal strength GMP Certified

100% vegan friendly

Additional Information

Store at room temperature.

Vegan friendly Made in USA No animal testing GMP Good manufacturing practice Quality products

Product Details

UPC / SKU X004KWQSMJ
DSLD Entry Date 2025-09-25
Product Type Other Combinations
Form Capsule
Brand Approved Science
DSLD ID 339385
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
PubMed DOI Cochrane
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
PubMed Cochrane
View all evidence for Thiamine →

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