🟢 93/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 73% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

2 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
73% Evidence Coverage

Supplement Facts — Evidence Check

50 mg (4167% DV)
📊 41.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 50mg
50 mg (3846% DV)
📊 38.5× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 50mg
50 mg (313% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 50mg UL 35mg
50 mg (2941% DV)
📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 50mg UL 100mg
680 mcg DFE (170% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 680.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 680mg UL 1.0mg
400 mcg (16667% DV)
📊 166.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.4mg
400 mcg (1333% DV)
📊 13.3× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.4mg
100 mg (2000% DV)
📊 20.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 100mg
Organic Proprietary Blend
440 mg
Enzyme Blend
25 mg
📊 Market median: 80.0mg (20 products) 📚 334 studies (Tier A: 8, B: 183)
This product: 10mg

Other Ingredients

Methylcellulose

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use: Take 2 capsules daily, preferably with a meal, or as directed by a healthcare professional.

⚠️ Warnings & Precautions

Caution: Do not exceed recommended dose.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before taking this or any dietary supplement.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before taking this or any dietary supplement.

🧪 Formulation Notes

High potency, Bio-Active B Vitamins with L-Methylfolate

Supports energy / nervous system / immune system Supports healthy skin, hair & eyes

Probiotics & digestive enzymes

All vegan

No GMO, meat, dairy, eggs, wheat, gluten, soy, nuts, shellfish, binders & fillers, coloring, preservatives, gelatin, yeast.

Manufactured at an FDA Registered Facility

Additional Information

GMP Good Manufacturing Practice Consistent Quality Made in the USA

Product Details

DSLD Entry Date 2025-06-25
Product Type Other Combinations
Form Capsule
DSLD ID 328380
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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