SAM-e Plus
94/100
This product looks safe
- Folate: 669mg is 669.0× the Tolerable Upper Intake Level (1.0mg)
- 100% of ingredients have research evidence
C
Label Compliance Grade
Product Label
Have a supplement label? Find it here.
Upload a photo of any supplement label to search our database of 92,312 products.
Safety Alerts
⚠️ Folate: 669mg is 669.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
2 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Supplement Facts — Evidence Check
30 mg
(188% DV)
✅ 2.1× RDA — within safe limits
📚 193 studies (Tier A: 5, B: 63)
2 mg
(118% DV)
✅ 1.5× RDA — within safe limits
📚 113 studies (Tier A: 3, B: 35)
669 mcg DFE
(167% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 669.0× (UL: 1.0 mg)
📚 225 studies (Tier A: 10, B: 105)
20 mcg
(833% DV)
📊 8.3× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
50 mg
(9% DV)
✅ Within RDA (0.1× RDA of 550 mg)
📚 36 studies (Tier A: 1, B: 7)
400 mg
📊 Market median: 200.0mg (52 products)
📚 10 studies (Tier A: 0, B: 6)
Other Ingredients
Hypromellose
Gellan
Silica
Magnesium Stearate
Label Claims — Verification
❓
All Other
All Other (97% of products)
Structure/Function (86% of products)
Nutrient (36% of products)
Target Groups
Adult (18 - 50 Years)
Dairy Free
Sugar Free
Product Information
📋 Directions for Use
Suggested use for adults: Two capsules, up to two times a day (preferably morning and evening), or as directed by your health care practitioner.
⚠️ Warnings & Precautions
This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.
🧪 Formulation Notes
SAM-e Plus with methylation & transulfuration factors
This product contains no yeast, wheat, soy, corn, milk, salt, sugar, artificial coloring, preservatives or flavoring.
This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.
Additional Information
Keep in a cool, dry place, tightly capped.
Product Details
Research Evidence
241
Research Sources
55
Avg Quality Score
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A
Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
A
Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
A
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
A
Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
B
Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Compare Similar Products
Serotone 5HTP 50 mg
Higher Nature
100
Serotone 5HTP 100 mg
Higher Nature
100
ChromeMate
NOW
100
ChromeMate 200 mcg
Protocol For Life Balance
100
Non Flush Niacin
Highland Laboratories
100