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SAM-e Plus

product on market Capsule Karuna Safety: 94/100
94/100

This product looks safe

  • Folate: 669mg is 669.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

This profile features B vitamins and choline, which are moderately supported by research for their roles in energy metabolism and cognitive function. While these nutrients are essential for neurological health, the overall evidence coverage for this specific combination is limited. The formulation maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 669mg is 669.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for SAM-e Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

30 mg (188% DV)
2.1× RDA — within safe limits 196 studies (A:5, B:63)
2 mg (118% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
669 mcg DFE (167% DV)
Exceeds UL by 669.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
20 mcg (833% DV)
8.3× RDA — above typical dose 139 studies (A:1, B:44)
50 mg (9% DV)
Within RDA (0.1× RDA) 38 studies (A:1, B:7)
400 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Hypromellose Gellan Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Suggested use for adults: Two capsules, up to two times a day (preferably morning and evening), or as directed by your health care practitioner.

Warnings & Precautions

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

Formulation Notes

SAM-e Plus with methylation & transulfuration factors

This product contains no yeast, wheat, soy, corn, milk, salt, sugar, artificial coloring, preservatives or flavoring.

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

Additional Information

Keep in a cool, dry place, tightly capped.

Metadata

Product Details

UPC / SKU0 18647 09125 1
DSLD Entry Date2025-01-23
Product TypeOther Combinations
FormCapsule
BrandKaruna
DSLD ID327124
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.