Serotone 5HTP 100 mg by Higher Nature — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Capsule(s) Serving Size

Other Combinations Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Niacin

30 mg NE (188% DV)

✅ 2.1× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 30mg UL 35mg

Vitamin B6

10 mg (714% DV)

📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 10mg UL 100mg

Folic Acid

100 mcg (50% DV)

✅ Within RDA (0.2× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.1mg UL 1.0mg

Biotin

50 mcg (100% DV)

✅ 1.7× RDA — within safe limits 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.05mg

Zinc

5 mg (50% DV)

✅ Within RDA (0.5× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 5mg UL 40mg

5-Hydroxytryptophan

100 mg

📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)

This product: 100mg

Other Ingredients

Rice Bran L-5-Hydroxytryptophan Hydroxypropyl Methylcellulose Niacin Zinc Citrate Pyridoxal 5-Phosphate Pyridoxine Hydrochloride Silicon Dioxide Magnesium Stearate Folic Acid Biotin

Label Claims — Verification

❓ All Other

All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

DIRECTIONS: Adults take 1 capsule a day preferably before bed, with a carbohydrate snack, or as your health professional advises. Do not exceed recommended daily intake.

⚠️ Warnings & Precautions

WARNING: Not advisable if pregnant or taking fenfluramine. Care should also be taken if being prescribed SSRIs.

Can cause drowsiness; do not drive or operate machinery if affected. If gastro-intestinal discomfort occurs, reduce intake.

Store in a cool, dry, steam free environment out of reach of children.

🧪 Formulation Notes

DOES NOT CONTAIN: Artificial colours, flavourings or preservatives, corn, dairy products, gluten, lactose, maize, salt, soya, sugar, wheat, yeast.

Suitable for vegetarians and vegans.

Additional Information

This product is not tested on animals.

Jar {Recycle} 1 PET Lid {Recycle} 5 PP

ULTIMATE NUTRITION

- 5HTP is an amino acid needed to produce serotonin. - Vits B3 & B6 contribute to normal psychological function.

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

SE1030 110 SE1-084-04

STORAGE: Store in a cool, dry, steam free environment out of reach of children.

Product Details

UPC / SKU 5 031013 100116

DSLD Entry Date 2015-02-25

Product Type Other Combinations

Form Capsule

Brand Higher Nature

DSLD ID 42149

Data Updated 2026-04-11

Research Evidence

241 Research Sources

55 Avg Quality Score

113 Meta Analysis

75 Systematic Review

32 Rct

11 Clinical Trial

3 Other

3 Regulatory Source

1 Cochrane Review

1 Narrative Review

1 Openfda Safety

A Niacin for primary and secondary prevention of cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases

Meta Analysis BMJ (Clinical research ed.) 2013

PubMed DOI

A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients

Meta Analysis BMJ (Clinical research ed.) 2014

PubMed DOI

A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

Meta Analysis Nature medicine 2024

PubMed DOI

A Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Meta Analysis Nature genetics 2010

PubMed DOI

A Genome-wide meta-analyses identify multiple loci associated with smoking behavior

Meta Analysis Nature genetics 2010

PubMed DOI

A Antidepressants for smoking cessation

Meta Analysis The Cochrane database of systematic reviews 2014

PubMed DOI

A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI Cochrane

B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis

Meta Analysis JAMA network open 2019

PubMed DOI

B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis

Meta Analysis JAMA 2016

PubMed DOI

View all evidence for Niacin →