Serotone 5HTP 50 mg by Higher Nature — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Capsule(s) Serving Size

Other Combinations Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Niacin

15 mg NE (94% DV)

✅ 1.1× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 15mg UL 35mg

Vitamin B6

5 mg (357% DV)

📊 3.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 5mg UL 100mg

Folic Acid

50 mcg (25% DV)

✅ Within RDA (0.1× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.05mg UL 1.0mg

Biotin

25 mcg (50% DV)

✅ Within RDA (0.8× RDA of 0.03 mg) 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.025mg

Zinc

2.5 mg (25% DV)

✅ Within RDA (0.2× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 2.5mg UL 40mg

5-Hydroxytryptophan

50 mg

📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)

This product: 50mg

Other Ingredients

Rice Bran Hydroxypropyl Methylcellulose L-5-Hydroxytryptophan Niacin Zinc Citrate Pyridoxal 5-Phosphate Pyridoxine Hydrochloride Silicon Dioxide Magnesium Stearate Folic Acid Biotin

Label Claims — Verification

❓ All Other

All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

DIRECTIONS: Adults take 1-2 capsules a day preferably before bed with a carbohydrate snack, or as your health professional advises.

⚠️ Warnings & Precautions

Store in a cool, dry, steam free environment out of reach of children.

Do not exceed recommended daily intake.

WARNING: Not advisable if pregnant or taking fenfluramine. Care should also be taken if being prescribed SSRIs.

Can cause drowsiness; do not drive or operate machinery if affected. If gastro-intestinal discomfort occurs, reduce intake.

🧪 Formulation Notes

DOES NOT CONTAIN: Artificial colours, flavourings or preservatives, corn, dairy products, gluten, lactose, maize, salt, soya, sugar, wheat, yeast.

Suitable for vegetarians and vegans.

Additional Information

SE5090 109 SE5-085-02

This product is not tested on animals.

Jar {Recycle} 1 PET Lid {Recycle} 5 PP

ULTIMATE NUTRITION

- 5HTP is an amino acid needed to produce serotonin. - Vits B3 & B6 contribute to normal psychological function.

STORAGE: Store in a cool, dry, steam free environment out of reach of children.

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Product Details

UPC / SKU 5 031013 100109

DSLD Entry Date 2015-01-23

Product Type Other Combinations

Form Capsule

Brand Higher Nature

DSLD ID 41869

Data Updated 2026-04-11

Research Evidence

241 Research Sources

55 Avg Quality Score

113 Meta Analysis

75 Systematic Review

32 Rct

11 Clinical Trial

3 Other

3 Regulatory Source

1 Cochrane Review

1 Narrative Review

1 Openfda Safety

A Niacin for primary and secondary prevention of cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases

Meta Analysis BMJ (Clinical research ed.) 2013

PubMed DOI

A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients

Meta Analysis BMJ (Clinical research ed.) 2014

PubMed DOI

A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

Meta Analysis Nature medicine 2024

PubMed DOI

A Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Meta Analysis Nature genetics 2010

PubMed DOI

A Genome-wide meta-analyses identify multiple loci associated with smoking behavior

Meta Analysis Nature genetics 2010

PubMed DOI

A Antidepressants for smoking cessation

Meta Analysis The Cochrane database of systematic reviews 2014

PubMed DOI

A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI Cochrane

B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis

Meta Analysis JAMA network open 2019

PubMed DOI

B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis

Meta Analysis JAMA 2016

PubMed DOI

View all evidence for Niacin →