Cognitive Balance

product on market Capsule NuMedica 🟢 Safety: 97/100
Brand: NuMedica
🟢 97/100

This product looks safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 64% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label Data

4 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
64% Evidence Coverage

Supplement Facts — Evidence Check

500 mg (3125% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 500mg UL 35mg
10 mg (588% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
250 mcg (10417% DV)
📊 104.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.25mg
100 mg (18% DV)
✅ Within RDA (0.2× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 100mg UL 3500mg
100 mg (24% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 100mg
500 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 500mg
500 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 500mg
400 mg
📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews
This product: 400mg
300 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 300mg
Phosphatidyl Serine
100 mg
200 mcg
📊 Market median: 0.15mg (41 products)
Median 0.15mg This product: 0.2mg

Other Ingredients

Hydroxypropyl Methylcellulose Ascorbyl Palmitate Microcrystalline Cellulose Silica natural Orange flavor Stevia Rice Flour

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take four capsules once per day with a meal or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Temporary flushing, itching or warming of the skin may occur. Do not use if you have gout, diabetes, liver dysfunction or are pregnant.

Do not use if you have gout, diabetes, liver dysfunction or are pregnant.

Keep out of reach of children.

🧪 Formulation Notes

Cognitive Balance provides support for optimal homocysteine and dopamine levels. Dopamine plays an important role in several brain functions, including cognition (learning and concentration), behavior, motor activity, sleep and mood.

Cognitive Balance features targeted ingredients shown to maximize vitamin transport to the nervous system and assist in the production and processing of the neurotransmitter dopamine.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

B Activated B-Vitamins

Professional quality formulas Optimal Methylation and dopamine support formula Neuro-immune support

GF Gluten-free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place.

cGMP Third-Party Certified Facility

Product Details

UPC / SKU 8 12527 01301 8
DSLD Entry Date 2025-02-23
Product Type Other Combinations
Form Capsule
Brand NuMedica
DSLD ID 323502
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI Cochrane
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
PubMed DOI
View all evidence for Niacin →

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