Home/ Supplements/ Niacin/ Cognitive Balance

Cognitive Balance

product on market Capsule NuMedica Safety: 97/100
97/100

This product looks safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 64% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins, choline, and magnesium, which are supported by moderate to strong evidence for maintaining neurological function and cognitive health. These nutrients act as essential cofactors in neurotransmitter synthesis and cellular energy production. The ingredient profile is associated with a high safety score of 97/100.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Cognitive Balance
Open Full PDF View on NIH DSLD →
Details

Label Data

4 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
64%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (3125% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)
10 mg (588% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
250 mcg (10417% DV)
104.2× RDA — above typical dose 139 studies (A:1, B:44)
100 mg (18% DV)
Within RDA (0.2× RDA) 38 studies (A:1, B:7)
100 mg (24% DV)
Within RDA (0.2× RDA) 316 studies (A:8, B:159)
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
400 mg
Market median: 500.0mg (193 products) 7 studies — no high-quality reviews
300 mg
Market median: 500.0mg (180 products) 5 studies (A:0, B:1)
Phosphatidyl Serine
100 mg
200 mcg
Market median: 0.15mg (41 products)

Other Ingredients

Hydroxypropyl Methylcellulose Ascorbyl Palmitate Microcrystalline Cellulose Silica natural Orange flavor Stevia Rice Flour
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take four capsules once per day with a meal or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Temporary flushing, itching or warming of the skin may occur. Do not use if you have gout, diabetes, liver dysfunction or are pregnant.

Do not use if you have gout, diabetes, liver dysfunction or are pregnant.

Keep out of reach of children.

Formulation Notes

Cognitive Balance provides support for optimal homocysteine and dopamine levels. Dopamine plays an important role in several brain functions, including cognition (learning and concentration), behavior, motor activity, sleep and mood.

Cognitive Balance features targeted ingredients shown to maximize vitamin transport to the nervous system and assist in the production and processing of the neurotransmitter dopamine.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

B Activated B-Vitamins

Professional quality formulas Optimal Methylation and dopamine support formula Neuro-immune support

GF Gluten-free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place.

cGMP Third-Party Certified Facility

Metadata

Product Details

UPC / SKU8 12527 01301 8
DSLD Entry Date2025-02-23
Product TypeOther Combinations
FormCapsule
BrandNuMedica
DSLD ID323502
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
Compare

Similar Products

Serotone 5HTP 50 mg
Higher Nature · Capsule
100
Serotone 5HTP 100 mg
Higher Nature · Capsule
100
ChromeMate
NOW · Capsule
100
ChromeMate 200 mcg
Protocol For Life Balance · Capsule
100
Non Flush Niacin
Highland Laboratories · Capsule
100
View all Niacin products →
Niacin research Best Niacin All Niacin products More from NuMedica View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.