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Methylation Support

product on market Capsule Akasha Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 44% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins and zinc, which are essential cofactors for methylation and homocysteine regulation. There is strong evidence supporting the role of folate and B12 in cardiovascular and neurological health. However, the overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Methylation Support
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
44%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1.6 mg (123% DV)
1.2× RDA — within safe limits 13 studies (A:0, B:1)
25 mg (1471% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Metafolin
1330 mcg DFE (333% DV)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
1.5 mg (14% DV)
Within RDA (0.1× RDA) 263 studies (A:6, B:134)
0.4 mg (17% DV)
Within RDA (0.2× RDA) 9 studies — no high-quality reviews
15 mcg (33% DV)
Within RDA (0.3× RDA) 3 studies — no high-quality reviews
N-Acetyl-L-Cysteine
600 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Hydroxypropyl Methylcellulose silicified Microcrystalline Celluloses Stearic Acid Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 2 capsules once daily, or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: if pregnant or nursing, or taking medications, please consult your healthcare practitioner before use.

Keep out of the reach of children.

To report adverse events call 866-649-4334.

Formulation Notes

Methylation support is a comprehensive formula that features calcium L-5-methyltetrahydrofolate- a body-ready, nature identical folate- along with N-acetyl-L-cysteine, vitamins B6 and methylated B12, and betaine HCl. Together, these nutrients support methylation, which promotes healthy homocysteine metabolism.

This product is non-GMO and gluten-free.

Support for healthy methylation & homocysteine metabolism

Vegetarian capsules

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Metadata

Product Details

UPC / SKU7 55571 94885 4
DSLD Entry Date2024-10-24
Product TypeOther Combinations
FormCapsule
BrandAkasha Naturals
DSLD ID313116
Data Updated2026-04-11
Research

Research Evidence

22
Research Sources
49
Avg Quality
8
Rct
4
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Cochrane Review
1
Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024 PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022 PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews PubMed DOI
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022 PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017 PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010 PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023 PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014 PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015 PubMed DOI
View all evidence for Riboflavin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.