Is 100 mg of Riboflavin safe?

This is 76.9× the recommended daily intake of 1.3 mg. While above typical doses, it may still be within safe limits (UL: None mg).

Vitamin B-2 100 Milligrams by NutraBio

100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
100% of ingredients have research evidence

A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Riboflavin is a critical cofactor for enzymes involved in energy metabolism and cellular function. There is strong evidence supporting its role in supporting mitochondrial health and overall metabolic processes. This ingredient is generally recognized as safe for supplementation at this dosage.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Open Full PDF View on NIH DSLD →

Details

Label Data

1 Vegetable Capsule(s)

Serving Size

120

Servings

Vitamin

Product Type

100%

Evidence Coverage

Ingredients

Supplement Facts — Evidence Check

Riboflavin

100 mg (5882% DV)

76.9× RDA — above typical dose 13 studies (A:0, B:1)

Other Ingredients

Rice Flour Vegetable Capsule

Claims

Label Claims — Verification

Unverified All Other

Unverified Structure/Function

Info

Product Information

Directions for Use

1 capsule daily with food Suggested Use: As a dietary supplement, take one (1) capsule daily, preferably with meals, or as directed by your physician.

Warnings & Precautions

Warning: NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN.

If you are pregnant, breast feeding, have known medical conditions (including kidney or liver disease) or are taking prescription or OTC medication(s) consult with your health care practitioner before using this product.

Formulation Notes

This product is Kosher, Vegetarian, Hypoallergenic, Non-GMO, Gluten Free & BSE/TSE Free.

Additional Information

Manufactured in a GMP & FDA inspected facility

100% Pure

Pharmaceutical Grade Lab Tested for Potency

120 Servings

Vegetable Capsule

Made in a GMP & FDA inspected facility

51816-001 B20380-000

Made in USA

Metadata

Product Details

UPC / SKU6 49908 51816 5

DSLD Entry Date2015-10-22

Product TypeVitamin

FormCapsule

BrandNutraBio

DSLD ID51277

Data Updated2026-04-11

Research

Research Evidence

Research Sources

Avg Quality

Rct

Meta Analysis

Clinical Trial

Systematic Review

Cochrane Review

Regulatory Source

B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

Systematic Review BMJ open 2024 PubMed DOI

B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis

Meta Analysis Nutritional neuroscience 2022 PubMed DOI

B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries

Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI

B Riboflavin supplements for blood pressure lowering in adults.

Cochrane Review The Cochrane database of systematic reviews PubMed DOI

B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis

Meta Analysis Nutrition reviews 2022 PubMed DOI

C Prophylaxis of migraine headaches with riboflavin: A systematic review

Systematic Review Journal of clinical pharmacy and therapeutics 2017 PubMed DOI

C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial

Rct Cephalalgia : an international journal of headache 2010 PubMed DOI

C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis

Meta Analysis International ophthalmology 2023 PubMed DOI

C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis

Meta Analysis The ocular surface 2014 PubMed DOI

C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial

Rct The journal of headache and pain 2015 PubMed DOI

View all evidence for Riboflavin →

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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.