🟢 92/100

This product looks safe

  • Niacin: 140mg is 4.0× the Tolerable Upper Intake Level (35mg)
  • Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
  • 90% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 140mg is 4.0× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
180 Servings
Vitamin Product Type
90% Evidence Coverage

Supplement Facts — Evidence Check

20 mg (1667% DV)
📊 16.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 20mg
20 mg (1538% DV)
📊 15.4× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 20mg
140 mg (875% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 4.0× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 140mg UL 35mg
20 mg (1176% DV)
📊 15.4× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 20mg UL 100mg
400 mcg DFE (100% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 400.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 400mg UL 1.0mg
400 mcg (16667% DV)
📊 166.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.4mg
400 mcg (1333% DV)
📊 13.3× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.4mg
150 mg (3000% DV)
📊 30.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 150mg
30 mg (5% DV)
✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 30mg UL 3500mg
20 mg
📊 16.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 20mg

Other Ingredients

Hydroxypropyl Methylcellulose Stearic Acid Magnesium Stearate Silica

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take one capsule once or twice daily, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Consult your healthcare practitioner prior to use.

Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Storage: Keep closed in a cool, dry place out of reach of children.

Professional use only

🧪 Formulation Notes

Coenzyme B-Complex contains the entire spectrum of B vitamins to support adrenal, neurological, and stress-related functions. It features activated forms of vitamins B2, B6, and B12; benfotiamine, a fat soluble, more physiologically active form of thiamin; and folate as Quatrefolic, which is proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF.

Does not contain: Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

B complex with benfotiamine and Quatrefolic

Manufactured in a GMP compliant facility.

Vegetarian caps

Additional Information

Storage: Keep closed in a cool, dry place out of reach of children.

This package is completely recyclable

Product Details

UPC / SKU 6 69439 84607 0
DSLD Entry Date 2024-04-23
Product Type Vitamin
Form Capsule
DSLD ID 310181
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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