MethylCare

product on market Capsule Metagenics 🟢 Safety: 100/100
Brand: Metagenics
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 44% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Vegetarian Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
44% Evidence Coverage

Supplement Facts — Evidence Check

1.6 mg (123% DV)
✅ 1.2× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 1.6mg
25 mg (1471% DV)
📊 19.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 25mg UL 100mg
Metafolin
1330 mcg DFE (333% DV)
1000 mcg (41667% DV)
📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
1.5 mg (14% DV)
✅ Within RDA (0.1× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 1.5mg UL 40mg
0.4 mg (17% DV)
✅ Within RDA (0.2× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 0.4mg UL 11mg
15 mcg (33% DV)
✅ Within RDA (0.3× RDA of 0.045 mg) 📚 2 studies — no high-quality reviews
RDA 0.045mg This product: 0.015mg UL 2mg
N-Acetyl-L-Cysteine
600 mg
500 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 500mg

Other Ingredients

Hydroxypropyl Methylcellulose silicified Microcrystalline Cellulose Stearic Acid Magnesium Stearate Silica

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take 2 capsules once daily, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: If pregnant or nursing, or taking medications, please consult your healthcare practitioner before use.

Keep out of the reach of children.

🧪 Formulation Notes

MethylCare is a comprehensive formula that features calcium L-5-methyltetrahydrofolate-a body-ready, nature identical folate-along with N-acetyl-L-cysteine, vitamins B6 and methylated B12, and betaine HCl. Together, these nutrients support methylation, which promotes healthy homocysteine metabolism.

This product is non-GMO and gluten-free.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Support for healthy methylation & homocysteine metabolism

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Practitioner Exclusive

Product Details

UPC / SKU 7 55571 94510 5
DSLD Entry Date 2023-08-23
Product Type Other Combinations
Form Capsule
Brand Metagenics
DSLD ID 295796
Data Updated 2026-04-11

Research Evidence

22 Research Sources
49 Avg Quality Score
8 Rct
4 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Cochrane Review
1 Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024
PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022
PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010
PubMed DOI Cochrane
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews
PubMed DOI Cochrane
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022
PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017
PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010
PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023
PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014
PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015
PubMed DOI
View all evidence for Riboflavin →

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