🟢 88/100

This product is generally safe

  • Niacin: 110mg is 3.1× the Tolerable Upper Intake Level (35mg)
  • Vitamin B6: 200mg is 2.0× the Tolerable Upper Intake Level (100mg)
  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 90% of ingredients have research evidence
F Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This complex contains B vitamins that support energy metabolism and neurological function, backed by strong clinical evidence. Thiamine, riboflavin, niacin, folate, and B6 are essential for cellular processes and neurotransmitter synthesis. The ingredient profile maintains a high safety score, indicating a low risk of adverse effects at standard dosages.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Niacin: 110mg is 3.1× the Tolerable Upper Intake Level (35mg)
⚠️ Vitamin B6: 200mg is 2.0× the Tolerable Upper Intake Level (100mg)
⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
120 Servings
Other Combinations Product Type
90% Evidence Coverage

Supplement Facts — Evidence Check

100 mg (8333% DV)
📊 83.3× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 100mg
15 mg (1154% DV)
📊 11.5× RDA — above typical dose 📚 13 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 15mg
110 mg (688% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 3.1× (UL: 35 mg) 📚 196 studies (Tier A: 5, B: 63)
RDA 14mg This product: 110mg UL 35mg
200 mg (11765% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.0× (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 200mg UL 100mg
667 mcg DFE (167% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 667mg UL 1.0mg
1000 mcg (41667% DV)
📊 416.7× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
400 mcg (1333% DV)
📊 13.3× RDA — above typical dose 📚 27 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.4mg
100 mg (2000% DV)
📊 20.0× RDA — above typical dose 📚 2 studies — no high-quality reviews
RDA 5mg This product: 100mg
12 mg (2% DV)
📊 Market median: 125.0mg (294 products) 📚 38 studies (Tier A: 1, B: 7)
RDA 550mg This product: 12mg UL 3500mg
25 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 25mg

Other Ingredients

Cellulose Water Ascorbyl Palmitate

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Recommendations: As a dietary supplement, take 1 capsule daily, with a meal.

⚠️ Warnings & Precautions

Warning: if you are pregnant or lactating, have a health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

Certified gluten-free by the Gluten-Free Certification Organization, www.gluten.org

B6 Complex with Metafolin L-5-MTHF; Broad-Spectrum B vitamin support with enhanced vitamin B6

Gluten-free, Non-GMO & hypoallergenic

Gluten-free, Non-GMO & hypoallergenic

Natural color variations can occur. Product can range from light yellow to bright yellow.

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

GFCO.org (Gluten-Free Certification Organization)

Product Details

UPC / SKU 7 66298 01758 7
DSLD Entry Date 2023-07-18
Product Type Other Combinations
Form Capsule
DSLD ID 295497
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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DSLD ID: 295497 Fetched: 2026-04-11
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