What the Evidence Says
✨ AI-generated · Qwen 3.6
· methodology
The B-vitamin complex, including thiamine, riboflavin, and folate, is supported by strong evidence for maintaining cellular energy metabolism and neurological function. Research indicates these nutrients are essential for DNA synthesis and neurotransmitter production. The overall safety profile for these ingredients is high, though evidence coverage for the specific formulation is limited.
AI-generated summary based on research evidence. Not medical advice.
Safety Alerts
⚠️ Niacin: 108mg is 3.1× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
64%
Evidence Coverage
Supplement Facts — Evidence Check
📊 104.2× RDA — above typical dose
📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg
This product: 125mg
📊 9.8× RDA — above typical dose
📚 13 studies (Tier A: 0, B: 1)
RDA 1.3mg
This product: 12.7mg
⚠️ Exceeds Tolerable Upper Intake Level by 3.1× (UL: 35 mg)
📚 196 studies (Tier A: 5, B: 63)
RDA 14mg
This product: 108mg
UL 35mg
📊 74.4× RDA — above typical dose (UL: 100 mg)
📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg
This product: 96.7mg
UL 100mg
⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg)
📚 226 studies (Tier A: 10, B: 105)
RDA 0.4mg
This product: 667mg
UL 1.0mg
📊 416.7× RDA — above typical dose
📚 139 studies (Tier A: 1, B: 44)
RDA 0.0024mg
This product: 1.0mg
📊 13.3× RDA — above typical dose
📚 27 studies (Tier A: 0, B: 11)
RDA 0.03mg
This product: 0.4mg
📊 20.0× RDA — above typical dose
📚 2 studies — no high-quality reviews
RDA 5mg
This product: 100mg
📊 Market median: 200.0mg (198 products)
📚 6 studies — no high-quality reviews
Other Ingredients
Cellulose
Water
Ascorbyl Palmitate
Label Claims — Verification
❓
Nutrient
❓
All Other
❓
Structure/Function
All Other (99% of products)
Structure/Function (83% of products)
Nutrient (47% of products)
Target Groups
Adult (18 - 50 Years)
Gluten Free
Product Information
📋 Directions for Use
Recommendations: As a dietary supplement, take 1 capsule, 1-2 times daily, with meals.
⚠️ Warnings & Precautions
Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children.
Use only if safety seal is intact.
🧪 Formulation Notes
Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org
With Metafolin L-5-MTHF:
Enhanced B-complex support for mitochondrial and nerve health
Gluten-free, Non-GMO & hypoallergenic
Gluten-free, Non-GMO & hypoallergenic
Additional Information
Store in a cool, dry place.
Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.
Scan to learn about our hypoallergenic supplements
GFCO.org (Gluten-Free Certification Organization)
Product Details
UPC / SKU
7 66298 01316 9
DSLD Entry Date
2023-08-23
Product Type
Other Combinations
Form
Capsule
Data Updated
2026-04-11
Research Evidence
100
Research Sources
56
Avg Quality Score
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
Systematic Review
The Cochrane database of systematic reviews
2013
Systematic Review
Nutritional neuroscience
2023
Meta Analysis
BMJ open
2022
Meta Analysis
Clinical nutrition (Edinburgh, Scotland)
2024
Systematic Review
Intensive care medicine
2022
Meta Analysis
Pain medicine (Malden, Mass.)
2020
Meta Analysis
Critical care medicine
2021
Meta Analysis
Complementary therapies in medicine
2022
Meta Analysis
Clinical and investigative medicine. Medecine clinique et experimentale
2023
Systematic Review
The Cochrane database of systematic reviews
2004
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