🟢 88/100

This product is generally safe

  • Niacin: 110mg is 3.1× the Tolerable Upper Intake Level (35mg)
  • Vitamin B6: 200mg is 2.0× the Tolerable Upper Intake Level (100mg)
  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 90% of ingredients have research evidence
F Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This complex contains B vitamins that support cellular energy production and neurological function. Research provides strong evidence for the role of these nutrients in metabolic processes and cognitive health. The formulation maintains a high safety profile for general use.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Niacin: 110mg is 3.1× the Tolerable Upper Intake Level (35mg)
⚠️ Vitamin B6: 200mg is 2.0× the Tolerable Upper Intake Level (100mg)
⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
90% Evidence Coverage

Supplement Facts — Evidence Check

100 mg (8333% DV)
📊 83.3× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 100mg
15 mg (1154% DV)
📊 11.5× RDA — above typical dose 📚 13 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 15mg
110 mg (688% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 3.1× (UL: 35 mg) 📚 196 studies (Tier A: 5, B: 63)
RDA 14mg This product: 110mg UL 35mg
200 mg (11765% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.0× (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 200mg UL 100mg
667 mcg DFE (167% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 667mg UL 1.0mg
1000 mcg (41667% DV)
📊 416.7× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
400 mcg (1333% DV)
📊 13.3× RDA — above typical dose 📚 27 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.4mg
100 mg (2000% DV)
📊 20.0× RDA — above typical dose 📚 2 studies — no high-quality reviews
RDA 5mg This product: 100mg
12 mg (2% DV)
📊 Market median: 125.0mg (294 products) 📚 38 studies (Tier A: 1, B: 7)
RDA 550mg This product: 12mg UL 3500mg
25 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 25mg

Other Ingredients

Cellulose Water Ascorbyl Palmitate

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Recommendations: As a dietary supplement, take 1 capsule daily, with a meal.

⚠️ Warnings & Precautions

Warning: if you are pregnant or lactating, have a health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

B6 Complex with Metafolin L-5-MTHF; Broad-Spectrum B vitamin support with enhanced vitamin B6

Gluten-free, Non-GMO & hypoallergenic

Natural color variations can occur. Product can range from light yellow to bright yellow.

Gluten-free, Non-GMO & hypoallergenic

Certified gluten-free by the Gluten-Free Certification Organization, www.gluten.org

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

GFCO.org (Gluten-Free Certification Organization)

Product Details

UPC / SKU 7 66298 01759 4
DSLD Entry Date 2023-05-24
Product Type Other Combinations
Form Capsule
DSLD ID 293897
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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DSLD ID: 293897 Fetched: 2026-04-11
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