Super B Energy Complex by Nature Made — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Softgel(s) Serving Size

60 Servings

Vitamin Product Type

88% Evidence Coverage

Supplement Facts — Evidence Check

Thiamine

1.5 mg (125% DV)

✅ 1.2× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 1.5mg

Riboflavin

1.7 mg (131% DV)

✅ 1.3× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 1.7mg

Niacin

20 mg (125% DV)

✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 20mg UL 35mg

Vitamin B6

2 mg (118% DV)

✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 2mg UL 100mg

Folate

665 mcg DFE (167% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 665.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 665mg UL 1.0mg

Vitamin B12

6 mcg (250% DV)

✅ 2.5× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.006mg

Biotin

300 mcg (1000% DV)

📊 10.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.3mg

Pantothenic Acid

10 mg (200% DV)

✅ 2.0× RDA — within safe limits 📚 1 studies — no high-quality reviews

RDA 5mg This product: 10mg

Other Ingredients

Soybean Oil Gelatin Dibasic Calcium Phosphate Glycerin Yellow Beeswax Rapeseed Lecithin Carmine

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested use: Adults, take 1 softgel daily with water and a meal.

⚠️ Warnings & Precautions

Store tightly closed, in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Caution: Biotin may interact with lab tests.

If you are taking medication or planning on undergoing any clinical lab testing, consult your physician before use.

🧪 Formulation Notes

Helps support nervous system function Vital for converting food into cellular energy

No synthetic dyes - colors derived from natural sources No artificial flavors No preservatives Gluten free

No synthetic dyes - colors derived from natural sources

USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org

Additional Information

#1 Pharmacist recommended vitamin & supplement brand Based on a survey of pharmacists who recommend branded vitamins and supplements. New pill color

USP Verified Dietary Supplement

Store tightly closed, in a cool, dry place, out of reach of children.

Product Details

UPC / SKU 0 31604 02865 7

DSLD Entry Date 2023-04-21

Product Type Vitamin

Form Softgel Capsule

Brand Nature Made

DSLD ID 293799

Data Updated 2026-04-11

Research Evidence

100 Research Sources

56 Avg Quality Score

48 Systematic Review

30 Meta Analysis

13 Rct

6 Clinical Trial

1 Cochrane Review

1 Regulatory Source

B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Systematic Review The Cochrane database of systematic reviews 2013

PubMed DOI Cochrane

B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

Systematic Review Nutritional neuroscience 2023

PubMed DOI

B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis

Meta Analysis BMJ open 2022

PubMed DOI

B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis

Systematic Review Intensive care medicine 2022

PubMed DOI

B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis

Meta Analysis Pain medicine (Malden, Mass.) 2020

PubMed DOI

B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Meta Analysis Critical care medicine 2021

PubMed DOI

B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2022

PubMed DOI

B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023

PubMed DOI

B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

Systematic Review The Cochrane database of systematic reviews 2004

PubMed Cochrane

View all evidence for Thiamine →