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Melatonin plus 5-HTP & Rhodiola

product on market Softgel Capsule Irwin Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 65% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin D3 is supported by strong evidence for maintaining bone health and immune function. The remaining listed components are basic macronutrients that provide minimal caloric value. Overall, the evidence coverage for this specific ingredient profile is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Melatonin plus 5-HTP & Rhodiola
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Liquid Softgel(s)
Serving Size
18
Servings
Other Combinations
Product Type
65%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
30 Calorie(s)
Total Fat
1.5 Gram(s) (2% DV)
Total Carbohydrates
1 Gram(s) (1% DV)
Protein
1 Gram(s)
25 mcg (125% DV)
1.7× RDA — within safe limits 608 studies (A:16, B:251)
10 mg (588% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mg (24% DV)
Within RDA (0.2× RDA) 316 studies (A:8, B:159)
1650 mg
Market median: 1000.0mg (212 products) 12 studies (A:0, B:3)
Market median: 400.0mg (142 products) 10 studies (A:0, B:2)
100 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)
Market median: 250.0mg (60 products) 7 studies (A:0, B:1)
Market median: 300.0mg (122 products) 22 studies (A:0, B:7)
Market median: 450.0mg (502 products) 28 studies (A:0, B:8)
50 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
Lemon Balm extract
50 mg
3 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)
BioPerine Complex
6 mg

Other Ingredients

Gelatin purified Water Glycerin Annatto Beeswax Soy Lecithin Maltodextrin Silicon Dioxide Titanium Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Use this product for occasional sleeplessness or on a daily basis to promote relaxation before bedtime.

Directions: (Adult) Take three (3) Liquid Soft-Gels with a glass (8oz) of water 30 minutes before bedtime to promote a restful sleep.

Warnings & Precautions

Usage Warnings: Do not use if safety seal is broken. Do not use in conjunction with alcoholic beverages when driving a vehicle, or while operating machinery.

Check with your doctor before using this product if you are using medication, including anti-depressants and pain medication or have any medical conditions including digestive disorders.

Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. Keep out of reach of children.

Contains: Soy

Formulation Notes

Melatonin plus 5-HTP & Rhodiola is an advanced and targeted sleep formula designed to help you get over your temporary sleep obstacles, tonight! This integrated formula is the perfect combination of Melatonin and L-Theanine to promote a restful sleep, plus it includes botanicals traditionally used in sleep aid and relaxing formulas such as, Rhodiola, Passionflower, Lemon Balm, and Chamomile, along with 5-HTP.

What makes us different: Liquid Soft-Gels -The nutrients in these easy-to-swallow Liquid Soft-Gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no nutritional value. Advanced Liquid Soft-Gels provide an optimum delivery system. Pass Quality Tested Guaranteed Quality Assurance - Irwin Naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency.

Patented BioPerine - BioPerine enhances the bioavailability, absorption and potency of many nutrients.

The perfect combination of Melatonin and L-Theanine for sleep & relaxation

No preservatives added.

Additional Information

Attaining restful and sustained sleep is fundamental to health and well-being. Unfortunately, our busy and demanding lifestyles do not always allow for adequate sleep, which over time can have deleterious effects on our health and sense of well-being.

Global Responsibility - Over the years we have donated to organizations that support the environment and the health of our children.

Store in a cool, dry place.

Questions: Contact Consumer Affairs 1-800-297-3273 Weekdays 8:00 AM to 5:00 PM (PST) 100+ Highly specialized products: www.IrwinNaturals.com

Sleep Calm Relax

Full Disclosure Ingredient Panel

Metadata

Product Details

UPC / SKU7 10363 59193 9
DSLD Entry Date2023-07-18
Product TypeOther Combinations
FormSoftgel Capsule
BrandIrwin Naturals
DSLD ID292081
Data Updated2026-04-11
Research

Research Evidence

291
Research Sources
55
Avg Quality
129
Meta Analysis
93
Systematic Review
51
Rct
11
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed DOI
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022 PubMed DOI
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022 PubMed DOI
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022 PubMed DOI
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023 PubMed DOI
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Melatonin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.