Melatonin plus 5-HTP & Rhodiola

product on market Softgel Capsule Irwin Naturals 🟢 Safety: 100/100
Brand: Irwin Naturals
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 65% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

3 Liquid Softgel(s) Serving Size
18 Servings
Other Combinations Product Type
65% Evidence Coverage

Supplement Facts — Evidence Check

Calories
30 Calorie(s)
Total Fat
1.5 Gram(s) (2% DV)
Total Carbohydrates
1 Gram(s) (1% DV)
Protein
1 Gram(s)
25 mcg (125% DV)
✅ 1.7× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.025mg UL 0.1mg
10 mg (588% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
100 mg (24% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 100mg
1650 mg
📊 Market median: 1000.0mg (212 products) 📚 12 studies (Tier A: 0, B: 3)
This product: 1650mg
150 mg
📊 Market median: 400.0mg (142 products) 📚 10 studies (Tier A: 0, B: 2)
This product: 150mg
100 mg
📊 Market median: 200.0mg (358 products) 📚 9 studies (Tier A: 0, B: 2)
This product: 100mg
100 mg
📊 Market median: 250.0mg (60 products) 📚 7 studies (Tier A: 0, B: 1)
This product: 100mg
100 mg
📊 Market median: 300.0mg (122 products) 📚 22 studies (Tier A: 0, B: 7)
This product: 100mg
50 mg
📊 Market median: 450.0mg (502 products) 📚 28 studies (Tier A: 0, B: 8)
This product: 50mg
50 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 50mg
Lemon Balm extract
50 mg
3 mg
📊 Market median: 3.0mg (984 products) 📚 236 studies (Tier A: 2, B: 109)
This product: 3mg UL 10mg
BioPerine Complex
6 mg

Other Ingredients

Gelatin purified Water Glycerin Annatto Beeswax Soy Lecithin Maltodextrin Silicon Dioxide Titanium Dioxide

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (100% of products) Structure/Function (86% of products) Nutrient (7% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Use this product for occasional sleeplessness or on a daily basis to promote relaxation before bedtime.

Directions: (Adult) Take three (3) Liquid Soft-Gels with a glass (8oz) of water 30 minutes before bedtime to promote a restful sleep.

⚠️ Warnings & Precautions

Usage Warnings: Do not use if safety seal is broken. Do not use in conjunction with alcoholic beverages when driving a vehicle, or while operating machinery.

Check with your doctor before using this product if you are using medication, including anti-depressants and pain medication or have any medical conditions including digestive disorders.

Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. Keep out of reach of children.

Contains: Soy

🧪 Formulation Notes

Melatonin plus 5-HTP & Rhodiola is an advanced and targeted sleep formula designed to help you get over your temporary sleep obstacles, tonight! This integrated formula is the perfect combination of Melatonin and L-Theanine to promote a restful sleep, plus it includes botanicals traditionally used in sleep aid and relaxing formulas such as, Rhodiola, Passionflower, Lemon Balm, and Chamomile, along with 5-HTP.

What makes us different: Liquid Soft-Gels -The nutrients in these easy-to-swallow Liquid Soft-Gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no nutritional value. Advanced Liquid Soft-Gels provide an optimum delivery system. Pass Quality Tested Guaranteed Quality Assurance - Irwin Naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency.

Patented BioPerine - BioPerine enhances the bioavailability, absorption and potency of many nutrients.

The perfect combination of Melatonin and L-Theanine for sleep & relaxation

No preservatives added.

Additional Information

Attaining restful and sustained sleep is fundamental to health and well-being. Unfortunately, our busy and demanding lifestyles do not always allow for adequate sleep, which over time can have deleterious effects on our health and sense of well-being.

Global Responsibility - Over the years we have donated to organizations that support the environment and the health of our children.

Store in a cool, dry place.

Questions: Contact Consumer Affairs 1-800-297-3273 Weekdays 8:00 AM to 5:00 PM (PST) 100+ Highly specialized products: www.IrwinNaturals.com

Sleep Calm Relax

Full Disclosure Ingredient Panel

Product Details

UPC / SKU 7 10363 59193 9
DSLD Entry Date 2023-07-18
Product Type Other Combinations
Form Softgel Capsule
Brand Irwin Naturals
DSLD ID 292081
Data Updated 2026-04-11

Research Evidence

291 Research Sources
55 Avg Quality Score
129 Meta Analysis
93 Systematic Review
51 Rct
11 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Interventions for preventing delirium in hospitalised non-ICU patients
Meta Analysis The Cochrane database of systematic reviews 2016
PubMed DOI
A Melatonin for preoperative and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI Cochrane
A Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ open 2022
PubMed DOI
B Pharmacological interventions for prevention of weight gain in people with schizophrenia
Meta Analysis The Cochrane database of systematic reviews 2022
PubMed DOI
B Melatonin for pre- and postoperative anxiety in adults
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI Cochrane
B Prevention of depression in adults with long-term physical conditions
Meta Analysis The Cochrane database of systematic reviews 2021
PubMed DOI
B Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Systematic Review Lancet (London, England) 2022
PubMed DOI
B Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Meta Analysis BMJ open 2023
PubMed DOI
B Second-generation antidepressants for preventing seasonal affective disorder in adults
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI
B Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Meta Analysis The Cochrane database of systematic reviews 2021
PubMed DOI
View all evidence for Melatonin →

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