All Day Immune Support Ester-C Effervescent 1000 mg + Electrolytes Natural Orange Flavor by Puritan's Pride — Ingredients, Evidence & Safety

🟢 88/100

This product is generally safe

Folate: 20mg is 20.0× the Tolerable Upper Intake Level (1.0mg)
Contains proprietary blend — exact ingredient amounts not disclosed
55% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 20mg is 20.0× the Tolerable Upper Intake Level (1.0mg)

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

10 Gram(s) Serving Size

21 Servings

Other Combinations Product Type

55% Evidence Coverage

Supplement Facts — Evidence Check

Calories

25 Calorie(s)

Total Carbohydrates

6 Gram(s) (2% DV)

Vitamin C

1026 mg (1140% DV)

Thiamine

0.38 mg (32% DV)

✅ Within RDA (0.3× RDA of 1.2 mg) 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 0.38mg

Riboflavin

0.43 mg (33% DV)

✅ Within RDA (0.3× RDA of 1.3 mg) 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 0.43mg

Niacin

5 mg (31% DV)

✅ Within RDA (0.4× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 5mg UL 35mg

Vitamin B6

10 mg (588% DV)

📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 10mg UL 100mg

Folate

20 mcg DFE (5% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 20.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 20mg UL 1.0mg

Vitamin B12

25 mcg (1042% DV)

📊 10.4× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.025mg

Pantothenic Acid

2.5 mg (50% DV)

✅ Within RDA (0.5× RDA of 5 mg) 📚 1 studies — no high-quality reviews

RDA 5mg This product: 2.5mg

Calcium

150 mg (12% DV)

Phosphorus

150 mg (12% DV)

✅ Within RDA (0.2× RDA of 700 mg) 📚 12 studies (Tier A: 0, B: 3)

RDA 700mg This product: 150mg UL 4000mg

Magnesium

60 mg (14% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 60mg

Zinc

2 mg (18% DV)

✅ Within RDA (0.2× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 2mg UL 40mg

Manganese

0.5 mg (22% DV)

✅ Within RDA (0.2× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 0.5mg UL 11mg

Chromium

5 mcg (14% DV)

✅ Within RDA (0.1× RDA of 0.035 mg) 📚 197 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.005mg

Chloride

90 mg (4% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 90mg

Sodium

100 mg (4% DV)

Potassium

280 mg (6% DV)

Proprietary Wellness Blend

58 mg

Other Ingredients

Fructose Maltodextrin Malic Acid Citric Acid Beta-Carotene natural Orange flavor Silica Cellulose

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (85% of products) Nutrient (54% of products) Approved Health (3% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: For adults, pour packet into 4-6 fl. oz. of water one daily. Stir or shake. Take Once Daily

Just take one packet daily with 4-6 fl. oz. of water and you are good to go!

⚠️ Warnings & Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if packet is torn or open.

🧪 Formulation Notes

Clinically studied to last longer than regular vitamin C

B Vitamins to support Energy 24 Hour Immune Support

No Artificial Flavor, No Artificial Sweetener, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish.

Ester-C has been clinically studied to stay in the white blood cells for up to 24 hours, which is longer than regular vitamin C. White blood cells are an important component of the immune system.

100% vegetarian

Non-GMO No artificial sweeteners

Ester-C Effervescent Packets offer 24-hour immune support in a delicious, natural orange flavored formula.

Our superior Ester-C The better vitamin C is clinically studied to last longer than regular vitamin C.

Along with essential vitamins, such as B-6 and B-12 to support energy metabolism and vital electrolytes to aid in metabolic hydration. Ester-C the better vitamin C, has your immune support covered.

Additional Information

Store at room temperature.

QA Quality Assured Made in the USA with select ingredients from around the world

TO REORDER ITEM # 26048 www.puritan.com 1-800-645-1030

21 - 10 g (0.35 oz.) Packets

Percent change (%) of vitamin C in white blood cells over 24 hours 50% 40% 30% 20% 10% 0 Ester-C Regular Vitamin C 2 hr 4 hr 8 hr 24 hr

Product Details

DSLD Entry Date 2023-06-22

Product Type Other Combinations

Form Powder

Brand Puritan's Pride

DSLD ID 286439

Data Updated 2026-04-11

Research Evidence

849 Research Sources

56 Avg Quality Score

450 Meta Analysis

152 Rct

137 Systematic Review

73 Clinical Trial

11 Regulatory Source

7 Other

7 Guideline

3 Openfda Safety

2 Cochrane Review

2 Observational

A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)

Meta Analysis The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI Cochrane

A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life

Meta Analysis The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI Cochrane

A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps

Systematic Review The Cochrane database of systematic reviews 2008

PubMed DOI Cochrane

A Calcium and vitamin D for increasing bone mineral density in premenopausal women

Systematic Review The Cochrane database of systematic reviews 2023

PubMed DOI Cochrane

A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019

PubMed DOI

A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021

PubMed DOI

A Calcium channel blockers versus other classes of drugs for hypertension

Systematic Review The Cochrane database of systematic reviews 2021

PubMed DOI

View all evidence for Electrolytes →