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Mega B-100

product on market Capsule Puritan's Pride Safety: 83/100
83/100

This product is generally safe

  • Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)
  • Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 73% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains a complex of B vitamins, including thiamine, riboflavin, and folate, which are supported by strong evidence for their roles in energy metabolism and cellular function. While these nutrients are essential for neurological health, the overall evidence coverage for this specific profile is limited. The product maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)

Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for Mega B-100
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
100
Servings
Other Combinations
Product Type
73%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg (8333% DV)
83.3× RDA — above typical dose 76 studies (A:0, B:33)
100 mg (7692% DV)
76.9× RDA — above typical dose 13 studies (A:0, B:1)
100 mg (625% DV)
Exceeds UL by 2.9× (UL: 35 mg) 196 studies (A:5, B:63)
100 mg (5882% DV)
76.9× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
1333 mcg DFE (333% DV)
Exceeds UL by 1333.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
100 mcg (4167% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
1000 mcg (3333% DV)
33.3× RDA — above typical dose 27 studies (A:0, B:11)
100 mg (2000% DV)
20.0× RDA — above typical dose 2 studies — no high-quality reviews
Market median: 500.0mg (9 products) 7 studies — no high-quality reviews
100 mcg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
Proprietary Blend
7.5 mg

Other Ingredients

Gelatin Dicalcium Phosphate Crospovidone Calcium Silicate Choline Bitartrate Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: For adults, take one (1) capsule daily, preferably with a meal.

Warnings & Precautions

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications, have any medical conditions, or are planning to undergo any clinical lab testing, consult your doctor before use.

Some supplements may interact with certain medications and/or interfere with certain lab tests. If any adverse reactions occur, stop use and consult your doctor.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Contains bioengineered food ingredients.

Formulation Notes

B-complex vitamin

Additional Information

Puritan's Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

Store at room temperature.

QA Quality Assured

B

Metadata

Product Details

UPC / SKU0 25077 10282 2
DSLD Entry Date2023-05-24
Product TypeOther Combinations
FormCapsule
BrandPuritan's Pride
DSLD ID285567
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.