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DefensePlus

product on market Tablet or Pill NutriBiotic Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 46% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Vitamin C and zinc have strong evidence for supporting immune function. Astragalus and reishi mushroom extract are associated with immune modulation, though research evidence for these botanicals is more limited. Grapefruit seed extract is commonly used for its antimicrobial properties.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for DefensePlus
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
90
Servings
Botanical with Nutrients
Product Type
46%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
125 mg (207% DV)
5 mg (33% DV)
Within RDA (0.5× RDA) 263 studies (A:6, B:134)
Market median: 250.0mg (50 products)
100 mg
Market median: 470.0mg (230 products) 9 studies (A:3, B:3)
Market median: 340.0mg (243 products) 3 studies — no high-quality reviews
Market median: 400.0mg (380 products) 36 studies (A:1, B:10)
Market median: 250.0mg (337 products) 127 studies (A:1, B:41)
Maitake Mushroom Extract
50 mg
50 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)
Shiitake Mushroom Extract
50 mg
Yarrow extract
50 mg

Other Ingredients

Microcrystalline Cellulose Dicalcium Phosphate Stearic Acid Dextrose Silicon Dioxide Magnesium Stearate Food Glaze Coating
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Suggested Use: At first signs of imbalance or depressed resistance, take one tablet daily with or without meals for two weeks.

Warnings & Precautions

Not recommended for children under 12 years of age.

Warning: Keep out of reach of children.

Do not exceed suggested use or use during pregnancy without consulting a licensed healthcare professional.

Formulation Notes

NutriBiotic DefensePlus tablets are a unique formulation combining grapefruit seed extract, vitamin C, echinacea extract, astragalus root, ginger root extract, Oregon grape root, yarrow extract, zinc, and the mushroom extracts of reishi, maitake, and shiitake and are used by healthcare professionals worldwide.

Each tablet has the same mg of grapefruit extract as 25 drops of NutriBiotic GSE Liquid Concentrate.

Maximum Strength

250 mg grapefruit seed extract with echinacea, astragalus, vitamin C, mushroom extracts, Oregon grape root & ginger root

Made without soy, milk, egg, yeast, wheat, sweeteners, preservatives, and GMOs. Gluten free

Additional Information

Please recycle

Not tested on animals

Nitro Pak Naturally fresh Bacteria free environment

Metadata

Product Details

UPC / SKU7 28177 01015 7
DSLD Entry Date2023-03-22
Product TypeBotanical with Nutrients
FormTablet or Pill
DSLD ID275863
Data Updated2026-04-11
Research

Research Evidence

371
Research Sources
54
Avg Quality
148
Meta Analysis
82
Systematic Review
71
Rct
62
Clinical Trial
2
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Other
1
Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024 PubMed DOI
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.