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B-Complex

product on market Capsule Core Nutritionals Safety: 92/100
92/100

This product looks safe

  • Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)
  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 90% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The B-complex ingredients, including thiamine, riboflavin, and folate, are supported by strong evidence for their roles in energy metabolism and neurological function. While these nutrients are well-established in clinical research, the overall evidence coverage for this specific formulation is limited. The profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)

Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B-Complex
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Other Combinations
Product Type
90%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg (8333% DV)
83.3× RDA — above typical dose 76 studies (A:0, B:33)
100 mg (7692% DV)
76.9× RDA — above typical dose 13 studies (A:0, B:1)
100 mg (625% DV)
Exceeds UL by 2.9× (UL: 35 mg) 196 studies (A:5, B:63)
100 mg (5882% DV)
76.9× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
680 mcg DFE (170% DV)
Exceeds UL by 680.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
100 mcg (4167% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
100 mcg (333% DV)
3.3× RDA — above typical dose 27 studies (A:0, B:11)
100 mg (2000% DV)
20.0× RDA — above typical dose 2 studies — no high-quality reviews
20 mg (4% DV)
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
100 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Hypromellose Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 capsule daily preferably with food.

Warnings & Precautions

Warning: This product is only intended for use in healthy adults 18 years of age or older.

Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product, or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication.

Discontinue use and consult your health care professional if you experience adverse reaction to this product. Discontinue use 2 weeks prior to surgery. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Warning: Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Formulation Notes

Energy Cardio Metabolism

Manufactured in a U.S. cGMP Facility

Additional Information

Protect from heat, light and moisture. Store at 10-25 Degrees C (50-77 Degrees F).

Metadata

Product Details

UPC / SKU6 72975 31579 5
DSLD Entry Date2022-06-16
Product TypeOther Combinations
FormCapsule
BrandCore Nutritionals
DSLD ID269385
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.