🟢 97/100

This product looks safe

  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 58% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Packet(s) Serving Size
20 Servings
Other Combinations Product Type
58% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s) (1% DV)
Vitamin C
90 mg (100% DV)
1.2 mg (100% DV)
✅ Within RDA (1.0× RDA of 1.2 mg) 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 1.2mg
1.3 mg (100% DV)
✅ Within RDA (1.0× RDA of 1.3 mg) 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 1.3mg
5.6 mg (35% DV)
✅ Within RDA (0.4× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 5.6mg UL 35mg
1.7 mg (100% DV)
✅ 1.3× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 1.7mg UL 100mg
667 mcg DFE (167% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 667mg UL 1.0mg
2.4 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.0024 mg) 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.0024mg
5 mg (100% DV)
✅ Within RDA (1.0× RDA of 5 mg) 📚 1 studies — no high-quality reviews
RDA 5mg This product: 5mg
Sodium
5 mg (1% DV)
📊 Market median: 80.0mg (20 products) 📚 334 studies (Tier A: 8, B: 183)
This product: 46mg

Other Ingredients

Fructooligosaccharides Citric Acid Malic Acid Vegetable juice Natural & Artificial flavor Sucralose

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Children 4 or More Years of Age Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Once daily

Directions for 12 years of age and older: For daily use, take one (1) single serve packet per day. Simply mix one packet with 8 or more ounces of water and enjoy. More water equals lighter flavor. For optimal results, continued daily use is suggested.

⚠️ Warnings & Precautions

Tamper Evident: Product is sealed within packets. Do not use if any part of the packet is torn, open or damaged. When first taking Culturelle, you may experience minor bloating, gas or intestinal gurgling which should subside with continued use. Consult your healthcare professional if symptoms persist after two weeks.

For questions, concerns or to report an adverse event, please call (800) 722-3476.

Not a reduced calorie food.

Keep out of reach of children.

Inform a healthcare professional before starting any dietary supplement, particularly if there is a known immune-compromised condition.

🧪 Formulation Notes

Unlike ordinary immune health products, Culturelle Immune Defense Packets have a breakthrough formula that easily transforms your water into an infusion of immune & energy supporting hydration.

70% Lactobacillus rhamnosus GG Probiotic Contains the power of probiotics which work in your digestive tract where 70% of your immune system resides. With 10 billion CFUs of scientifically studied Lactobacillus rhamnosus GG, it helps balance your immune responses by working in your body’s microbiome. B vitamins Vitamin C boost Vitamin C & B Vitamins Plus, a specially formulated blend of vitamin C & energy-inducing B vitamins to deliver extra immune support and sustained energy levels.

Immune Support Formula Together, they work naturally with your body to help keep you feeling your best and your immune system going strong all day long.

Immune support formula

Probiotics Vitamin C & B vitamins

Based on the number of Lactobacillus rhamnosus GG clinical studies, as of January 2021. B vitamins support energy through metabolic function.

Guaranteed potency through date on box when stored as directed.

Meets the FDA’s guidelines for gluten-free.

Most clinically researched strain in the world Guaranteed purity & potency

Dairy - Gluten - Soy - Free

Probiotic + vitamin C & B vitamins

Probiotics 24 hour immune support Helps support your natural immune defenses Promotes all-day energy

Mixed berry Natural & artificial flavors Flavored packets

Allergy friendly

Free from Milk - Wheat - Eggs Tree Nuts - Peanuts

Additional Information

Trust Your Gut Daily to Culturelle

Storage Instructions: Store Culturelle in a cool, dry place away from direct sunlight.

Our brand values We’re on a mission to inspire better health & wellness for you & your family. We believe in integrity, so we hold ourselves to the highest standards of truth. We believe in the natural power of your body’s microbiome, & in scientific research & products that will unlock its full potential. We believe in uncompromising quality, safety & proven efficacy. We believe in empowering you to embrace every day with confidence.

With the #1 clinically studied probiotic

Product Details

UPC / SKU 0 49100 40078 5
DSLD Entry Date 2022-06-16
Product Type Other Combinations
Form Powder
Brand Culturelle
DSLD ID 267566
Data Updated 2026-04-11

Research Evidence

371 Research Sources
54 Avg Quality Score
148 Meta Analysis
82 Systematic Review
71 Rct
62 Clinical Trial
2 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Other
1 Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021
View all evidence for Vitamin C →

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