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Advanced B Complex

product on market Capsule AOR Advanced Orthomolecular Research Advanced Safety: 92/100
92/100

This product looks safe

  • Niacin: 353mg is 10.1× the Tolerable Upper Intake Level (35mg)
  • Folate: 555mg is 555.0× the Tolerable Upper Intake Level (1.0mg)
  • 90% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains essential B vitamins that support energy metabolism and neurological function. Research provides strong evidence for the roles of thiamine, riboflavin, and folate in cellular health. Overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 353mg is 10.1× the Tolerable Upper Intake Level (35mg)

Folate: 555mg is 555.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Advanced B Complex
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Other Combinations
Product Type
90%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg (8333% DV)
83.3× RDA — above typical dose 76 studies (A:0, B:33)
7.5 mg (577% DV)
5.8× RDA — above typical dose 13 studies (A:0, B:1)
353 mg (2206% DV)
Exceeds UL by 10.1× (UL: 35 mg) 196 studies (A:5, B:63)
100 mg (5882% DV)
76.9× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
555 mcg DFE (139% DV)
Exceeds UL by 555.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
500 mcg (1667% DV)
16.7× RDA — above typical dose 27 studies (A:0, B:11)
300 mg (6000% DV)
60.0× RDA — above typical dose 2 studies — no high-quality reviews
240 mg (44% DV)
Within RDA (0.4× RDA) 38 studies (A:1, B:7)
393 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Microcrystalline Cellulose Dicalcium Phosphate Capsule Silicon Dioxide Hydroxypropyl Cellulose Sodium Stearyl Fumarate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 capsule 1-3 time daily with food, or as directed by a qualified health care practitioner.

Warnings & Precautions

Do not use if safety seal is broken.

Warning: Consult your physician before use if you are pregnant, lactating, have a medical condition, or if you're taking any medication.

Keep out of reach of children.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Formulation Notes

GMP Manufacturing Quality assured Independent testing

Discussion: Advanced B Complex was designed to provide the most advanced forms of B vitamins in the most scientifically discerning ratios available. Advanced B Complex contains benfotiamine, a form of vitamin B1 that is more bioavailable than other forms of thiamin, as well as pyridoxal-5'phosphate (P5P), methylcobalamin and L-5-methyltetrahydrofolate, bioactive forms of vitamin B6, B12 and folate respectively.

Biologically active full-spectrum B-complex

Vegan

Non-GMO Gluten Free

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Product of Canada

Additional Information

Store tightly sealed in a cool, dry place.

Metadata

Product Details

UPC / SKU6 24917 08167 1
DSLD Entry Date2022-05-19
Product TypeOther Combinations
FormCapsule
BrandAOR Advanced Orthomolecular Research Advanced
DSLD ID263431
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.