🟢 87/100

This product is generally safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 64% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Capsule(s) Serving Size
83 Servings
Other Combinations Product Type
64% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C
500 mg (833% DV)
100 mg (6667% DV)
📊 83.3× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 100mg
100 mg (5882% DV)
📊 76.9× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 100mg
500 mg (2500% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 14.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 500mg UL 35mg
100 mg (5000% DV)
📊 76.9× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 100mg UL 100mg
300 mcg (75% DV)
✅ Within RDA (0.7× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.3mg UL 1.0mg
50 mcg (833% DV)
📊 20.8× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.05mg
15 mcg (5% DV)
✅ Within RDA (0.5× RDA of 0.03 mg) 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.015mg
250 mg (2500% DV)
📊 50.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 250mg
ChromeMate
200 mcg (167% DV)
Proprietary Blend
245 mg

Other Ingredients

Gelatin Rice Flour Vegetable Lubricant Maltodextrin Mannitol

Label Claims — Verification

Nutrient
All Other
All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Directions: One to three capsules daily, or more, as directed by a health care professional.

⚠️ Warnings & Precautions

Sold only for dispensing by a licensed health professional.

Not to be used by pregnant or lactating women.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of the reach of children.

🧪 Formulation Notes

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

Stress B complex with Vitamin C

Additional Information

GMP Good Manufacturing Practice Certified GMP Compliant 21 CFR 111

Product Details

UPC / SKU 3 51821 09702 2
DSLD Entry Date 2022-04-11
Product Type Other Combinations
Form Capsule
DSLD ID 261767
Data Updated 2026-04-11

Research Evidence

371 Research Sources
54 Avg Quality Score
148 Meta Analysis
82 Systematic Review
71 Rct
62 Clinical Trial
2 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Other
1 Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021
View all evidence for Vitamin C →

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