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Coenzyme B-Complex

product on market Capsule Natural Grocers by Vitamin Cottage Safety: 92/100
92/100

This product looks safe

  • Vitamin B3: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 90% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This blend of B vitamins supports energy metabolism and neurological function. Research provides strong evidence for the roles of B1, B2, B3, B6, and folate in cellular health. However, the overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Vitamin B3: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Coenzyme B-Complex
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetarian Capsule(s)
Serving Size
120
Servings
Other Combinations
Product Type
90%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (833% DV)
8.3× RDA — above typical dose 76 studies (A:0, B:33)
10 mg (769% DV)
7.7× RDA — above typical dose 13 studies (A:0, B:1)
50 mg NE (313% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
20 mg (1176% DV)
15.4× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
667 mcg DFE (167% DV)
Exceeds UL by 667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
400 mcg (16667% DV)
166.7× RDA — above typical dose 139 studies (A:1, B:44)
200 mcg (667% DV)
6.7× RDA — above typical dose 27 studies (A:0, B:11)
95 mg (1900% DV)
19.0× RDA — above typical dose 2 studies — no high-quality reviews
25 mg (5% DV)
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
25 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Microcrystalline Cellulose Capsule Silica Rice Bran
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: As a dietary supplement, adults take one (1) vegetarian capsule daily, or as directed by a health care professional.

Warnings & Precautions

Caution: As with any supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, or are under medical supervision for any reason.

Keep out of reach of children.

For serious adverse event reporting call (877) 455-2826.

Formulation Notes

Contains no: Sugar, salt, dairy, yeast, corn, wheat, gluten, soy, preservatives, magnesium stearate, artificial colors or flavors.

Metabolism support

GF (Gluten free)

Vegetarian

Additional Information

Store in a cool, dry place and away from direct light.

GMP Good Manufacturing Practice

Made in USA

BPA Free

Metadata

Product Details

UPC / SKU8 49327 00364 2
DSLD Entry Date2022-02-23
Product TypeOther Combinations
FormCapsule
BrandNatural Grocers by Vitamin Cottage
DSLD ID260721
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.