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Homocysteine Plus

product on market Capsule NutriCology Safety: 95/100
95/100

This product looks safe

  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 62% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Riboflavin, B6, folate, B12, and zinc are supported by strong evidence for their role in regulating homocysteine levels. These nutrients act as essential cofactors in the methylation cycle to support cardiovascular and neurological health. The ingredient profile is associated with a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Homocysteine Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Other Combinations
Product Type
62%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (769% DV)
7.7× RDA — above typical dose 13 studies (A:0, B:1)
30 mg (1765% DV)
23.1× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
667 mcg DFE (167% DV)
Exceeds UL by 667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
400 mcg (16667% DV)
166.7× RDA — above typical dose 139 studies (A:1, B:44)
5 mg (45% DV)
Within RDA (0.5× RDA) 263 studies (A:6, B:134)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
L-Serine
100 mg
L-Glutathione
50 mg

Other Ingredients

Hydroxypropyl Methylcellulose Magnesium Stearate Microcrystalline Cellulose Silicon Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use As a dietary supplement, 1 capsule one or two times daily, or as directed by a healthcare practitioner.

Formulation Notes

Provides primary nutrients to facilitate the breakdown of homocysteine into methionine and other metabolites, including coenzyme forms of vitamins B2, B6, folate, and B12, plus Setria glutathione, zinc, trimethyglycine, and L-serine.

Variations in product color may occur.

Homocysteine Plus with Setria Glutathione

Hypoallergenic

Additional Information

Keep in a cool, dry place, tightly capped.

Metadata

Product Details

UPC / SKU7 13947 52580 1
DSLD Entry Date2022-01-22
Product TypeOther Combinations
FormCapsule
BrandNutriCology
DSLD ID258599
Data Updated2026-04-11
Research

Research Evidence

22
Research Sources
49
Avg Quality
8
Rct
4
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Cochrane Review
1
Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024 PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022 PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews PubMed DOI
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022 PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017 PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010 PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023 PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014 PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015 PubMed DOI
View all evidence for Riboflavin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.