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Knee, Hip & Joint Complex

product on market Capsule SigmaCeutical Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines MSM, hyaluronic acid, and turmeric, which have moderate evidence for supporting joint health and reducing inflammation. Cetyl Myristoleate and Holy Basil are included, though clinical evidence for their specific efficacy in joint complexes is limited. The profile maintains a high safety score with no significant contraindications noted.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Knee, Hip & Joint Complex
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Cetyl Myristoleate 20% Complex
100 mg
Market median: 100.0mg (173 products)
MSM
100 mg
Market median: 1000.0mg (2 products)
Market median: 500.0mg (138 products) 2 studies — no high-quality reviews
Market median: 450.0mg (254 products) 243 studies (A:0, B:100)
Market median: 250.0mg (337 products) 127 studies (A:1, B:41)
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
Market median: 375.0mg (171 products) 31 studies (A:1, B:14)
50 mg
Market median: 200.0mg (136 products) 3 studies — no high-quality reviews
Skullcap 4:1 extract
25 mg
Market median: 167.0mg (311 products) 183 studies (A:0, B:65)
2.5 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)

Other Ingredients

Gelatin Rice powder Vegetable Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: 1 capsule taken 1 to 2 times daily preferably with meals or as directed by a healthcare professional.

Warnings & Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Formulation Notes

Supports comfort and flexibility

With CMO, turmeric & MSM

Additional Information

Store in a cool, dry place.

Good Manufacturing Practice Sourced from a GMP Certified Facility Quality Assured Made In USA

Please go to www.sigmaceutical.com for special discounts & offers! SigmaCeutical The sum of all health

Metadata

Product Details

UPC / SKUB0731QF7Y4
DSLD Entry Date2021-11-19
Product TypeOther Combinations
FormCapsule
BrandSigmaCeutical
DSLD ID255964
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
9
Rct
3
Clinical Trial
1
Systematic Review
1
Guideline
B Dressings and topical agents containing hyaluronic acid for chronic wound healing
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
B Effect of laughter exercise versus 0.1% sodium hyaluronic acid on ocular surface discomfort in dry eye disease: non-inferiority randomised controlled trial
Rct BMJ (Clinical research ed.) 2024 PubMed DOI
B Expert consensus on hyaluronic acid injections for knee osteoarthritis: a patient-centered approach.
Guideline Aging clinical and experimental research 2026 PubMed DOI
C The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial
Rct Nutrients 2024 PubMed DOI
C Effects of ozone combined with articular injection of sodium hyaluronate on patients with knee osteoarthritis and their inflammatory factors and hemorheological indices.
Rct African health sciences PubMed DOI
C The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial.
Rct Medicine PubMed DOI
C Liquid combination of hyaluronan, glucosamine, and chondroitin as a dietary supplement for knee osteoarthritis patients with moderate knee pain: A randomized controlled study.
Rct Medicine PubMed DOI
C Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial.
Rct The journal of sexual medicine PubMed DOI
C PMCF Study to Evaluate Performance and Safety of 'Hyaluronic Acid (HA)-Based Eyedrops' Used to Relieve Dry Eye Symptoms
Clinical Trial ClinicalTrials.gov 2022
C Effect of Hyaluronic Acid Oral Supplementation on Sexual and Urinary Symptoms of Women With Recurrent Urinary Tract Infections
Clinical Trial ClinicalTrials.gov 2022
View all evidence for Hyaluronic Acid →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.