MTHFR Renew
100/100
This product looks safe
- No ingredients exceed tolerable upper intake levels
- 55% of ingredients have research evidence
A
Label Compliance Grade
What the Evidence Says
AI-generated · Qwen 3.6 · methodologyThis formula contains B vitamins and zinc, which are essential for methylation and cellular function. Strong evidence supports the role of folate and B12 in homocysteine regulation and neurological health. However, the overall evidence coverage for this specific combination is limited.
AI-generated summary based on research evidence. Not medical advice.
Label
Product Label
Details
Label Data
2 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
55%
Evidence Coverage
Ingredients
Supplement Facts — Evidence Check
50 mg
(2941% DV)
38.5× RDA — above typical dose (UL: 100 mg)
114 studies (A:3, B:35)
1000 mcg
(250% DV)
2.5× RDA — within safe limits
226 studies (A:10, B:105)
500 mcg
(20833% DV)
208.3× RDA — above typical dose
139 studies (A:1, B:44)
50 mg
(1000% DV)
10.0× RDA — above typical dose
2 studies — no high-quality reviews
5 mg
(45% DV)
Within RDA (0.5× RDA)
263 studies (A:6, B:134)
50 mg
Within RDA (0.1× RDA)
38 studies (A:1, B:7)
N-Acetyl L-Cysteine
100 mg
80 mg
Market median: 496.0mg (192 products)
20 studies — no high-quality reviews
50 mg
Market median: 500.0mg (223 products)
24 studies (A:0, B:1)
Serine
50 mg
25 mg
Market median: 420.0mg (227 products)
Other Ingredients
Rice Flour
Natural flavor
Vegetable Capsules
Vegetable Magnesium Stearate
Claims
Label Claims — Verification
Unverified
All Other
Unverified
Structure/Function
Info
Product Information
Directions for Use
Suggested Use: As a dietary supplement, take one capsule daily, or as directed by a physician.
Warnings & Precautions
Tamper evident. Do not use if seal is broken.
Keep out of reach of children.
Formulation Notes
Made in the USA
Additional Information
Store in a cool, dry place.
Clinically proven
Metadata
Product Details
UPC / SKU6 07111 48199 7
DSLD Entry Date2021-08-23
Product TypeOther Combinations
FormCapsule
BrandPhysician Designed
DSLD ID249575
Data Updated2026-04-11
Research
Research Evidence
153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A
Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
A
Homocysteine lowering interventions for preventing cardiovascular events
A
Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
A
Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
A
Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
B
Prophylactic drug management for febrile seizures in children
B
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
B
The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
B
Pyridoxine (vitamin B6) supplementation in pregnancy
B
Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.