High Strength B Complex by Higher Nature — Ingredients, Evidence & Safety

🟢 96/100

This product looks safe

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
90% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label Data

1 Capsule(s) Serving Size

30 Servings

Other Combinations Product Type

90% Evidence Coverage

Supplement Facts — Evidence Check

Thiamine

50 mg (4545% DV)

📊 41.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 50mg

Riboflavin

50 mg (3571% DV)

📊 38.5× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 50mg

Niacin

50 mg (313% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 50mg UL 35mg

Vitamin B6

10 mg (714% DV)

📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 10mg UL 100mg

Folic Acid

200 mcg (100% DV)

✅ Within RDA (0.5× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.2mg UL 1.0mg

Vitamin B12

20 mcg (800% DV)

📊 8.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.02mg

Biotin

50 mcg (100% DV)

✅ 1.7× RDA — within safe limits 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.05mg

Pantothenic Acid

50 mcg (833% DV)

📊 Market median: 9.0mg (620 products) 📚 1 studies — no high-quality reviews

RDA 5mg This product: 0.05mg

Choline

50 mg

✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)

RDA 550mg This product: 50mg UL 3500mg

Inositol

20 mg

📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)

This product: 20mg

Other Ingredients

Choline Bitartrate Hydroxypropyl Methylcellulose Thiamine Calcium D-Pantothenate Riboflavin Nicotinamide Microcrystalline Cellulose Inositol Pyridoxal 5-Phosphate Magnesium Stearate Pyridoxine Hydrochloride Silicon Dioxide Calcium L-5-Methyltetrahydrofolate Pteroylglutamic Acid Biotin Methylcobalamin

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Children 4 or More Years of Age Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Adults and children aged 13 and over take 1 capsule a day with meals, ideally with breakfast. Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

⚠️ Warnings & Precautions

Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Storage: Store in a cool, dry place out of reach of children.

🧪 Formulation Notes

Free from: Artificial colours, flavourings or preservatives, dairy products, gluten, lactose, salt, soya, sugar, wheat, yeast.

Vegetarian & vegan

Complete B vitamin formula

Advanced formula Optimal benefit

Perfect for hectic lifestyles

Feel energized with Vitamins B2, B3, B6 and B12 which help reduce tiredness and fatigue and are needed for energy release Aids mental performance with pantothenic acid (B5)

Additional Information

NRV = Nutrient Reference Value

This product has not been tested on animals. Everyday Essentials

Storage: Store in a cool, dry place out of reach of children.

Product Details

UPC / SKU 5 031013 108846

DSLD Entry Date 2021-04-22

Product Type Other Combinations

Form Capsule

Brand Higher Nature

DSLD ID 245966

Data Updated 2026-04-11

Research Evidence

100 Research Sources

56 Avg Quality Score

48 Systematic Review

30 Meta Analysis

13 Rct

6 Clinical Trial

1 Cochrane Review

1 Regulatory Source

B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Systematic Review The Cochrane database of systematic reviews 2013

PubMed DOI Cochrane

B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

Systematic Review Nutritional neuroscience 2023

PubMed DOI

B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis

Meta Analysis BMJ open 2022

PubMed DOI

B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis

Systematic Review Intensive care medicine 2022

PubMed DOI

B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis

Meta Analysis Pain medicine (Malden, Mass.) 2020

PubMed DOI

B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Meta Analysis Critical care medicine 2021

PubMed DOI

B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2022

PubMed DOI

B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023

PubMed DOI

B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

Systematic Review The Cochrane database of systematic reviews 2004

PubMed Cochrane

View all evidence for Thiamine →