Homocysteine Supreme
96/100
This product looks safe
- NatureFolate Blend: 2.4mg is 2.4× the Tolerable Upper Intake Level (1.0mg)
- 70% of ingredients have research evidence
C
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ NatureFolate Blend: 2.4mg is 2.4× the Tolerable Upper Intake Level (1.0mg)
Label Data
2 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
70%
Evidence Coverage
Supplement Facts — Evidence Check
50 mg
(2941% DV)
📊 38.5× RDA — above typical dose
📚 12 studies (Tier A: 0, B: 1)
50 mg
(2500% DV)
📊 38.5× RDA — above typical dose (UL: 100 mg)
📚 113 studies (Tier A: 3, B: 35)
2400 mcg
(600% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.4× (UL: 1.0 mg)
📚 225 studies (Tier A: 10, B: 105)
1000 mcg
(16667% DV)
📊 416.7× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
10 mg
(3% DV)
📊 Market median: 4002.0mg (1 products)
📚 20 studies (Tier A: 0, B: 2)
5 mg
(33% DV)
✅ Within RDA (0.5× RDA of 11 mg)
📚 258 studies (Tier A: 6, B: 134)
Trimethylgylcine
500 mg
100 mg
✅ Within RDA (0.2× RDA of 550 mg)
📚 36 studies (Tier A: 1, B: 7)
Serine
100 mg
N-Acetyl-Cysteine
100 mg
Other Ingredients
Microcrystalline Cellulose
Silicon Dioxide
Vegetable Stearate
Label Claims — Verification
❓
All Other
All Other (99% of products)
Structure/Function (85% of products)
Nutrient (48% of products)
No Claim (1% of products)
Target Groups
Adult (18 - 50 Years)
Gluten Free
Product Information
📋 Directions for Use
Recommended Use: As a dietary supplement, take two capsules per day with meals, or as directed by your health care practitioner.
⚠️ Warnings & Precautions
KEEP OUT OF REACH OF CHILDREN.
🧪 Formulation Notes
Does not contain gluten.
Additional Information
Notice: Color, size or shape may appear different between lots.
HYS120
For Professional Use Only
Manufactured in an NSF GMP Registered Facility
STORE IN A COOL, DRY PLACE.
Guaranteed GMP COMPLIANT Products
Product Details
UPC / SKU
8 79452 00273 9
DSLD Entry Date
2013-06-25
Product Type
Other Combinations
Form
Capsule
Brand
Designs for Health
DSLD ID
23173
Data Updated
2026-04-11
Research Evidence
22
Research Sources
49
Avg Quality Score
8
Rct
4
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Cochrane Review
1
Regulatory Source
B
Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
B
Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
B
Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
B
Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
C
Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
C
The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
C
Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
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