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Homocysteine Supreme

product on market Capsule Designs for Health Safety: 96/100
96/100

This product looks safe

  • NatureFolate Blend: 2.4mg is 2.4× the Tolerable Upper Intake Level (1.0mg)
  • 70% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The combination of B vitamins and magnesium is supported by strong evidence for lowering homocysteine levels. Riboflavin, B6, and B12 act as essential cofactors in the methylation process to regulate cardiovascular risk markers. These ingredients are generally well-tolerated and maintain a high safety profile.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

NatureFolate Blend: 2.4mg is 2.4× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Homocysteine Supreme
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
70%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

50 mg (2941% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (2500% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
2400 mcg (600% DV)
Exceeds UL by 2.4× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (16667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
10 mg (3% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
5 mg (33% DV)
Within RDA (0.5× RDA) 263 studies (A:6, B:134)
Trimethylgylcine
500 mg
100 mg
Within RDA (0.2× RDA) 38 studies (A:1, B:7)
Serine
100 mg
N-Acetyl-Cysteine
100 mg

Other Ingredients

Microcrystalline Cellulose Silicon Dioxide Vegetable Stearate
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Recommended Use: As a dietary supplement, take two capsules per day with meals, or as directed by your health care practitioner.

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

Formulation Notes

Does not contain gluten.

Additional Information

Notice: Color, size or shape may appear different between lots.

HYS120

For Professional Use Only

Manufactured in an NSF GMP Registered Facility

STORE IN A COOL, DRY PLACE.

Guaranteed GMP COMPLIANT Products

Metadata

Product Details

UPC / SKU8 79452 00273 9
DSLD Entry Date2013-06-25
Product TypeOther Combinations
FormCapsule
BrandDesigns for Health
DSLD ID23173
Data Updated2026-04-11
Research

Research Evidence

22
Research Sources
49
Avg Quality
8
Rct
4
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Cochrane Review
1
Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024 PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022 PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews PubMed DOI
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022 PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017 PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010 PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023 PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014 PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015 PubMed DOI
View all evidence for Riboflavin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.