🟢 97/100

This product looks safe

  • Niacin: 60mg is 1.7× the Tolerable Upper Intake Level (35mg)
  • 38% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 60mg is 1.7× the Tolerable Upper Intake Level (35mg)

Label Data

11.66 Fluid Ounce(s) Serving Size
12 Servings
Other Combinations Product Type
38% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s) (1% DV)
60 mg (300% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.7× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 60mg UL 35mg
1 mg (50% DV)
✅ Within RDA (0.8× RDA of 1.3 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 1mg UL 100mg
500 mcg (125% DV)
✅ 1.2× RDA — within safe limits 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.5mg UL 1.0mg
70 mcg (1167% DV)
📊 29.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.07mg
Sodium
125 mg (5% DV)
6 Gram(s)
📊 Market median: 2000.0mg (275 products)
Median 2000.0mg This product: 6mg
CarnoSyn
3.2 Gram(s)
1.5 Gram(s)
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 1.5mg
📊 Market median: 500.0mg (143 products)
This product: 1mg
1 Gram(s)
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 1mg
C4 Ultimate Energy & Focus Blend
708 mg

Other Ingredients

Water Natural & Artificial flavors Sucralose Acesulfame Potassium FD&C Yellow #6

Label Claims — Verification

All Other
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

🧪 Formulation Notes

300mg caffeine

Naturally & artificially flavored

Made in the U.S.A. using U.S. and imported ingredients and components.

CarnoSyn Carnosine Synthesizer AlphaSize Zembrin

Additional Information

The most explosive pre-workout

12 pack 12 - 11.66 fl oz bottles (139.9 fl oz) 12 - 345 mL bottles (4.11 L)

For compete patent and trademark information, visit cellucor.com/c4ultimate

Product Details

DSLD Entry Date 2020-06-24
Product Type Other Combinations
Form Liquid
Brand Cellucor
DSLD ID 228729
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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