🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 58% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Softgel(s) Serving Size
30 Servings
Other Combinations Product Type
58% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Fat
1 Gram(s) (2% DV)
Cholesterol
5 mg (1% DV)
30 mg (1500% DV)
📊 23.1× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 30mg UL 100mg
400 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.4mg UL 1.0mg
750 mcg (12500% DV)
📊 312.5× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.75mg
10 mg (67% DV)
✅ Within RDA (0.9× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 10mg UL 40mg
Calamarine Oil Concentrate
1250 mg
200 mg
📊 Market median: 500.0mg (861 products) 📚 60 studies (Tier A: 4, B: 13)
This product: 200mg
50 mg
📊 Market median: 100.0mg (283 products) 📚 142 studies (Tier A: 1, B: 64)
This product: 50mg UL 1200mg
10 mg
📊 Market median: 10.0mg (105 products) 📚 1 studies (Tier A: 0, B: 1)
This product: 10mg
2 mg
📊 Market median: 4.0mg (32 products)
This product: 2mg

Other Ingredients

Gelatin Medium Chain Triglycerides Gamma Cyclodextrin Glycerin Sunflower Lecithin yellow Beeswax Silicon Dioxide Sunflower Oil Lemon flavor Annatto seed extract

Label Claims — Verification

All Other
All Other (97% of products) Structure/Function (87% of products) Nutrient (18% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Doctor's suggested use: Take 2 softgels once daily with a meal. For added support, take 2 softgels twice daily with a meal.

⚠️ Warnings & Precautions

Note: Pregnant or lactating women should consult a health care professional before taking this product.

Keep out of reach of children.

Additional Information

America's #1 integrative cardiologist

Friend Of The Sea Calamarine CoQ10 Pure NSF Contents Tested & Certified

Product Details

DSLD Entry Date 2019-10-23
Product Type Other Combinations
Form Softgel Capsule
Brand Dr. Sinatra
DSLD ID 207811
Data Updated 2026-04-11

Research Evidence

8 Research Sources
46 Avg Quality Score
4 Rct
2 Clinical Trial
1 Systematic Review
B Systematic review of carotenoid concentrations in human milk and infant blood
Systematic Review Nutrition reviews 2022
C No CFH or ARMS2 Interaction with Omega-3 Fatty Acids, Low versus High Zinc, or β-Carotene versus Lutein and Zeaxanthin on Progression of Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report No. 18
Rct Ophthalmology 2019
C Consumption of Hen Eggs Enriched with n-3 Polyunsaturated Fatty Acids, Selenium, Vitamin E and Lutein Incites Anti-Inflammatory Conditions in Young, Healthy Participants - A Randomized Study.
Rct Frontiers in bioscience (Landmark edition)
C Effect of Dietary Supplementation with Lutein, Zeaxanthin, and Elderberries on Dry Eye Disease (DED) and Immunity: A Randomized Controlled Trial.
Rct Nutrients
C Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration.
Rct Ophthalmology
C The Influence of Lutein Supplements on Age-related Macular Degeneration
Clinical Trial ClinicalTrials.gov 2007
D Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60
Clinical Trial ClinicalTrials.gov 2005
D Lutein
View all evidence for Lutein →

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